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          Institute: MPI für Biochemie     Collection: Molecular Biology (A. Ullrich)     Display Documents

ID: 31383.0, MPI für Biochemie / Molecular Biology (A. Ullrich)
Molecular portrait of human kidney carcinomas: The cDNA microarray profiling of kinases and phosphatases involved in the cell signaling control
Authors:Cheburkin, Y. V.; Knyazeva, T. G.; Peter, S.; Knyazev, Y. P.; Karelin, M. I.; Shkolnik, M. I.; Evtushenko, V. I.; Hanson, K.; Ullrich, A.; Knyazev, P. G.
Date of Publication (YYYY-MM-DD):2002-05
Title of Journal:Molecular Biology
Journal Abbrev.:Mol. Biol.
Issue / Number:3
Start Page:376
End Page:384
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Hybridization with cDNA arrays was used to obtain expression profiles of 214 protein-tyrosine kinase, protein-tyrosine phosphatase, dual specificity phosphatase, and other genes for kidney carcinomas (KC) and normal kidney tissues of 34 patients and for seven carcinoma cell lines. Computer analysis revealed three clusters of genes coexpressed in KC. The proliferating- cell gene cluster included MET, VIM, MYC, TOM, PCNA. The neoangiogenesis and blood-cell gene cluster included LCK, HCK, FGR, MAIM, CSFR1, VEGF, FLT1, and KDR. The cluster corresponding to normal, differentiated kidney cells included ERBB2 (HER2) for receptor protein-tyrosine kinase, several phosphatase genes (PTPRE, PTPRB, DUSP9), and EGF. The results suggested that MET, DUSP9, PCNA, TOM, and VIM may serve as diagnostic and prognostic markers in KC. Tubulin and topoisomerase II were assumed to be promising targets for cell proliferation inhibitors in KC.
Free Keywords:molecular oncology; kidney carcinoma; cDNA arrays; expression; clusters; oncogencs; tyrosine kinases; tyrosine phosphatases; dual specificity phosphatases
Comment of the Author/Creator:Date: 2002, MAY-JUN
External Publication Status:published
Document Type:Article
Communicated by:N.N.
Affiliations:MPI für Biochemie/Molecular Biology (A. Ullrich)
External Affiliations:Minist Hlth Russian Federat, Res Inst Roentgenol & Radiol, St; Petersburg 197758, Russia; Minist Hlth Russian Federat, Res Inst Roentgenol & Radiol, St Petersburg 197758, Russia; Minist Hlth Russian Federat, Petrol Inst Oncol, St Petersburg 197758, Russia; Klinikum Darmstadt, Urol Klin, D-64283 Darmstadt, Germany
Identifiers:ISI:000176468800015 [ID No:1]
ISSN:0026-8933 [ID No:2]
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