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          Institute: MPI für Biochemie     Collection: Cell Biology (E. A. Nigg)     Display Documents



ID: 31389.0, MPI für Biochemie / Cell Biology (E. A. Nigg)
The centrosome cycle
Authors:Meraldi, P.; Nigg, E. A.
Language:English
Date of Publication (YYYY-MM-DD):2002-06-19
Title of Journal:FEBS Letters
Journal Abbrev.:FEBS Lett.
Volume:521
Issue / Number:1-3
Start Page:9
End Page:13
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:The centrosome is the major microtubule-organizing center of animal cells. It influences cell shape and polarity and directs the formation of the bipolar mitotic spindle. Numerical and structural centrosome aberrations have been implicated in disease, notably cancer. In dividing cells, centrosomes need to be duplicated and segregated in synchrony with chromosomes. This centrosome cycle requires a series of structural and functional transitions that are regulated by both phosphorylation and proteolysis. Here we summarize recent information on the regulation of the centrosome cycle and its coordination with the chromosomal cell cycle. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
Free Keywords:centrosome duplication; centrosome maturation; centrosome separation; centriole disorientation; protein phosphorylation; proteolysis
Comment of the Author/Creator:Date: 2002, JUN 19
External Publication Status:published
Document Type:Article
Communicated by:N.N.
Affiliations:MPI für Biochemie/Cell Biology (E.A. Nigg)
Identifiers:ISI:000176443600003 [ID No:1]
ISSN:0014-5793 [ID No:2]
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