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          Institute: MPI für biophysikalische Chemie     Collection: Molekulare Entwicklungsbiologie (Prof. Herbert Jäckle)     Display Documents



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ID: 314735.0, MPI für biophysikalische Chemie / Molekulare Entwicklungsbiologie (Prof. Herbert Jäckle)
Misexpression screen in Drosophila melanogaster aiming to reveal novel factors involved in formation of body parts
Authors:Grieder, N. C.; Charlafti, I.; Kloter, U.; Jaeckle, H.; Schaefer, U.; Gehring, W. J.
Language:English
Date of Publication (YYYY-MM-DD):2007-04
Title of Journal:Genetics
Volume:175
Issue / Number:4
Start Page:1707
End Page:1718
Review Status:not specified
Audience:Not Specified
Abstract / Description:To identify novel factors that lead a fly imaginal disc to adopt its developmental fate, we carried out a modular dominant misexpression screen in imaginal discs. We have identified two factors that appear to change the fate of the respective body structure and appear to lead to the transformation of a body part. In one mutant line, notum tissue, normally derived from wing imaginal tissue, formed close to the site of the sternopleural bristles, which are leg disc derivatives. In the other line, the arista is transformed into a tubular structure, resembling an abnormal leg. We found that ectopic expression of abrupt was responsible for this potential transformation of the arista.
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für biophysikalische Chemie/Abt. Herbert Jäckle / 170
Identifiers:URL:http://www.genetics.org/cgi/content/full/175/4/170...
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