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          Institute: MPI für biophysikalische Chemie     Collection: Molekulare Entwicklungsbiologie (Prof. Herbert Jäckle)     Display Documents



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ID: 316968.0, MPI für biophysikalische Chemie / Molekulare Entwicklungsbiologie (Prof. Herbert Jäckle)
Dual lipolytic control of body fat storage and mobilization in Drosophila
Authors:Groenke, S.; Mueller, G.; Hirsch, J.; Fellert, S.; Andreou, A.; Haase, T.; Jaeckle, H.; Kuehnlein, R. P.
Language:English
Date of Publication (YYYY-MM-DD):2007-05-08
Title of Journal:PLoS Biology
Volume:5
Issue / Number:6
Start Page:1248
End Page:1256
Full name of Issue-Editor(s):Steve O’Rahilly
Review Status:not specified
Audience:Not Specified
Abstract / Description:Energy homeostasis is a fundamental property of animal life, providing a genetically fixed balance between fat storage and mobilization. The importance of body fat regulation is emphasized by dysfunctions resulting in obesity and lipodystrophy in humans. Packaging of storage fat in intracellular lipid droplets, and the various molecules and mechanisms guiding storage-fat mobilization, are conserved between mammals and insects. We generated a Drosophila mutant lacking the receptor (AKHR) of the adipokinetic hormone signaling pathway, an insect lipolytic pathway related to ß-adrenergic signaling in mammals. Combined genetic, physiological, and biochemical analyses provide in vivo evidence that AKHR is as important for chronic accumulation and acute mobilization of storage fat as is the Brummer lipase, the homolog of mammalian adipose triglyceride lipase (ATGL). Simultaneous loss of Brummer and AKHR causes extreme obesity and blocks acute storage-fat mobilization in flies. Our data demonstrate that storage-fat mobilization in the fly is coordinated by two lipocatabolic systems, which are essential to adjust normal body fat content and ensure lifelong fat-storage homeostasis.
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für biophysikalische Chemie/Abt. Herbert Jäckle / 170
MPI für biophysikalische Chemie/AG Ronald Kühnlein
External Affiliations:Therapeutic Department Metabolic Diseases, SanofiAventis Pharma Deutschland GmbH, Frankfurt, Germany
Identifiers:URL:http://biology.plosjournals.org/perlserv/?request=...
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