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          Institute: MPI für Biochemie     Collection: Structural Biology (W. Baumeister)     Display Documents



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ID: 318571.0, MPI für Biochemie / Structural Biology (W. Baumeister)
Base-pair formation of self-organizing rna amphiphiles within two dimensions
Authors:Rädler, U.; Heiz, C.; Luisi, P. L.; Tampe, R.
Date of Publication (YYYY-MM-DD):1998-11-10
Title of Journal:Langmuir
Volume:14
Issue / Number:23
Start Page:6620
End Page:6624
Review Status:not specified
Audience:Not Specified
Abstract / Description:In an attempt to get a better insight in specific base pairing by self-organization of DNA or RNA, the synthesis of a complete set of monoalkyl ribonucleotides is described. The thermodynamic phase and mixing properties of these self-organizing RNA amphiphiles were analyzed within two dimensions using hbn balance technique. The pure compounds form stable monolayers at the air-water interface on a physiological buffer. In analogy to base-paired RNA or DNA in solution, the monolayers were mostly stabilized by complexing the phosphate groups by calcium or magnesium ions. By use of mixtures of RNA amphiphiles, specific recognition and base-pair formation of monoalkyl phospho adenosine/uridine were demonstrated. [References: 42]
Free Keywords:Air-water-interface; Molecular recognition; Supramolecular chemistry; Phospholipase-d; Sds micelles; Adenine; Monolayers; Membranes; Lipids; Dna.; Physical chemistry/chemical physics.
External Publication Status:published
Document Type:Article
Communicated by:Anton Hillebrand
Affiliations:MPI für Biochemie/Structural Biology (W. Baumeister)
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