Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Institute: MPI für Biochemie     Collection: Structural Biology (W. Baumeister)     Display Documents



ID: 318607.0, MPI für Biochemie / Structural Biology (W. Baumeister)
Macromolecular electron microscopy in the era of structural genomics
Authors:Baumeister, W.; Steven, A. C.
Date of Publication (YYYY-MM-DD):2000
Title of Journal:Trends in Biochemical Sciences
Journal Abbrev.:Trends Biochem.Sci
Volume:25
Issue / Number:12
Start Page:624
End Page:631
Audience:Not Specified
Abstract / Description:Macromolecular machines carry out many cellular functions. Cryo-electron microscopy (cryo-EM) is emerging as a powerful method for studying the structure, assembly and dynamics of such macromolecules, and their interactions with substrates. With resolutions still improving, 'single-particle' analyses are already depicting secondary structure. Moreover, cryo-EM can be combined in several ways with X-ray diffraction to enhance the resolution of cryo-EM and the applicability of crystallography. Electron tomography holds promise for visualizing machines at work inside cells. [References: 62]
Free Keywords:X-ray crystallography; Cryoelectron microscopy; 8-angstrom resolution; Atomic model; Virus; Crystallization; Visualization; Channel; Reconstruction; Tomography.; Biochemistry & Biophysics in Current Contents(R)/Life Sciences.
External Publication Status:published
Document Type:Article
Communicated by:Anton Hillebrand
Affiliations:MPI für Biochemie/Structural Biology (W. Baumeister)/
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.