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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilung 2 - Biochemistry (E. Izaurralde)     Display Documents



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ID: 331577.0, MPI für Entwicklungsbiologie / Abteilung 2 - Biochemistry (E. Izaurralde)
mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons.
Authors:Behm-Ansmant, Isabelle; Kashima, I.; Rehwinkel, J.; Sauliere, J.; Wittkopp, Nadine; Izaurralde, Elisa
Language:English
Date of Publication (YYYY-MM-DD):2007-06-19
Title of Journal:FEBS Lett. 2007 Jun 19;581(15):2845-5
Volume:581
Issue / Number:15
Start Page:2845
End Page:2845
Sequence Number of Article:17531985
Review Status:not specified
Audience:Not Specified
Abstract / Description:Nonsense-mediated mRNA decay (NMD) is an mRNA surveillance pathway which ensures the rapid degradation of mRNAs containing premature translation termination codons (PTCs or nonsense codons), thereby preventing the accumulation of truncated and potentially harmful proteins. In this way, the NMD pathway contributes to suppressing or exacerbating the clinical manifestations of specific human genetic disorders. Studies in model organisms have led to the identification of the effectors of the NMD pathway, and illuminated the mechanisms by which premature stops are discriminated from natural stops, so that only the former trigger rapid mRNA degradation. These studies are providing important insights that will aid the development of new treatments for at least some human genetic diseases.
External Publication Status:published
Document Type:Article
Communicated by:root
Affiliations:MPI für Entwicklungsbiologie
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