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          Institute: MPI für molekulare Genetik     Collection: Department of Human Molecular Genetics     Display Documents

ID: 334619.0, MPI für molekulare Genetik / Department of Human Molecular Genetics
Radiation induced late effects in two affected individuals of the Lilo radiation accident.
Authors:Scherthan, Harry; Abend, Michael; Müller, Kerstin; Beine, Christina; Braselmann, Herbert; Zitzelsberger, Horst; Köhn, Frank M.; Pillekamp, Hans; Schiener, Ralf; Das, Oliver; Peter, Ralf U.; Herzog, Gerhard; Tzschach, Andreas; Doerr, Harald; Fliedner, Theodor M.; Meineke, Viktor
Date of Publication (YYYY-MM-DD):2007-05-01
Title of Journal:Radiation Research
Journal Abbrev.:Radiat. Res.
Issue / Number:5
Start Page:615
End Page:623
Copyright:© 2007 ProQuest All rights reserved.
Review Status:not specified
Audience:Experts Only
Abstract / Description:Radiation-Induced Late Effects in Two Affected Individuals of the Lilo Radiation Accident. Radiat. Res. 167, 615-623 (2007). Radiation exposure leads to a risk for long-term deterministic and stochastic late effects. Two individuals exposed to protracted photon radiation in the radiological accident at the Lilo Military site in Georgia in 1997 received follow-up treatment and resection of several chronic radiation ulcers in the Bundeswehr Hospital Ulm, Germany, in 2003. Multi-parameter analysis revealed that spermatogenetic arrest and serum hormone levels in both patients had recovered compared to the status in 1997. However, we observed a persistence of altered T-cell ratios, increased ICAM1 and ^b1-integrin expression, and aberrant bone marrow cells and lymphocytes with significantly increased translocations 6 years after the accident. This investigation thus identified altered end points still detectable years after the accident that suggest persistent genomic damage as well as epigenetic effects in these individuals, which may be associated with an elevated risk for the development of further late effects. Our observations further suggest the development of a chronic radiation syndrome and indicate follow-up parameters in radiation victims.
External Publication Status:published
Document Type:Article
Communicated by:Hans-Hilger Ropers
Affiliations:MPI für molekulare Genetik
External Affiliations:1.Bundeswehr Institute of Radiobiology, Neuherbergstr. 11, D-80937 Munich, Germany;
2.GSF-National Research Center for Environment and Health, Institute of Molecular Radiation Biology, Neuherberg, Germany;
3.Department of Dermatology and Allergy Biederstein, Technische Universitaet Muenchen, 80802 Munich, Germany; 4.Department of Dermatology, Bundeswehr Hospital Ulm, Germany;
5.Center for Vascular Surgery and Dermatology Blaustein, Ulm, Germany; Department of Internal Medicine, Bundeswehr Hospital, Koblenz, Germany;
6.Radiation Medicine Research Group, Faculty of Medicine, University of Ulm, Germany.
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