Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Institute: MPI für molekulare Genetik     Collection: Department of Vertebrate Genomics     Display Documents



  history
ID: 335198.0, MPI für molekulare Genetik / Department of Vertebrate Genomics
Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules
Authors:Nonhoff, Ute; Ralser, Markus; Welzel, Franziska; Piccini, Ilaria; Balzereit, Daniela; Yaspo, Marie-Laure; Lehrach, Hans; Krobitsch, Sylvia
Language:English
Date of Publication (YYYY-MM-DD):2007-04
Title of Journal:Molecular Biology of the Cell
Journal Abbrev.:Mol Biol Cell
Volume:18
Issue / Number:4
Start Page:1385
End Page:1396
Copyright:© 2007 by The American Society for Cell Biology
Review Status:not specified
Audience:Experts Only
Abstract / Description:Tight control of translation is fundamental for eukaryotic cells, and deregulation of proteins implicated contributes to numerous human diseases. The neurodegenerative disorder spinocerebellar ataxia type 2 is caused by a trinucleotide expansion in the SCA2 gene encoding a lengthened polyglutamine stretch in the gene product ataxin-2, which seems to be implicated in cellular RNA-processing pathways and translational regulation. Here, we substantiate a function of ataxin-2 in such pathways by demonstrating that ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6, a component of P-bodies and stress granules, representing cellular structures of mRNA triage. We discovered that altered ataxin-2 levels interfere with the assembly of stress granules and cellular P-body structures. Moreover, ataxin-2 regulates the intracellular concentration of its interaction partner, the poly(A)-binding protein, another stress granule component and a key factor for translational control. Thus, our data imply that the cellular ataxin-2 concentration is important for the assembly of stress granules and P-bodies, which are main compartments for regulating and controlling mRNA degradation, stability, and translation.
Comment of the Author/Creator:Address correspondence to: Sylvia Krobitsch krobitsc@molgen.mpg.de
External Publication Status:published
Document Type:Article
Communicated by:Hans Lehrach
Affiliations:MPI für molekulare Genetik
Identifiers:ISSN:1059-1524
DOI:10.1091/mbc.E06-12-1120
URL:http://www.molbiolcell.org/cgi/doi/10.1091/mbc.E06...
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.