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          Institute: MPI für molekulare Genetik     Collection: Ribosome Research Groups     Display Documents



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ID: 337070.0, MPI für molekulare Genetik / Ribosome Research Groups
The oxazolidinone class of drugs find their orientation on the ribosome
Authors:Wilson, Daniel N.; Nierhaus, Knud H.
Language:English
Date of Publication (YYYY-MM-DD):2007-05-25
Title of Journal:Molecular Cell
Journal Abbrev.:Mol Cell
Volume:26
Issue / Number:4
Start Page:460
End Page:462
Copyright:© 2008 Elsevier B.V.
Review Status:not specified
Audience:Experts Only
Abstract / Description:Recent studies by Leach et al. (2007) in Molecular Cell identify the orientation of the oxazolidinone antibiotic linezolid at the peptidyltransferase center of bacterial and mitochondrial ribosomes, providing a structural basis for the mechanism of drug action and observed side effects.
External Publication Status:published
Document Type:Article
Communicated by:Ribosome Group
Affiliations:MPI für molekulare Genetik
External Affiliations:Gene Center and Department for Chemistry and Biochemistry, University of Munich, Feodor-Lynen-Strasse 25, D-81377 Munich, Germany
Identifiers:ISSN:1097-2765
DOI:10.1016/j.molcel.2007.05.008
URL:http://www.sciencedirect.com/science?_ob=MImg&_ima...
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