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          Institute: MPI für molekulare Genetik     Collection: Ribosome Research Groups     Display Documents



  history
ID: 337074.0, MPI für molekulare Genetik / Ribosome Research Groups
The weird and wonderful world of bacterial ribosome regulation
Authors:Wilson, Daniel N.; Nierhaus, Knud H.
Language:English
Date of Publication (YYYY-MM-DD):2007-05
Title of Journal:Critical Reviews in Biochemistry and Molecular Biology (Boca Raton, FL)
Journal Abbrev.:Crit Rev Biochem Mol Biol
Volume:42
Issue / Number:3
Start Page:187
End Page:219
Copyright:© 2007 Informa plc
Review Status:not specified
Audience:Experts Only
Abstract / Description:In every organism, translation of the genetic information into functional proteins is performed on the ribosome. In Escherichia coli up to 40% of the cell's total energy turnover is channelled toward the ribosome and protein synthesis. Thus, elaborate networks of translation regulation pathways have evolved to modulate gene expression in response to growth rate and external factors, ranging from nutrient deprivation, to chemical (pH, ionic strength) and physical (temperature) fluctuations. Since the fundamental players involved in regulation of the different phases of translation have already been extensively reviewed elsewhere, this review focuses on lesser known and characterized factors that regulate the ribosome, ranging from processing, modification and assembly factors, unusual initiation and elongation factors, to a variety of stress response proteins.
Free Keywords:Assembly; Biogenesis; Protein synthesis; Ribosome; RNA; Translation regulation
External Publication Status:published
Document Type:Article
Communicated by:Ribosome Group
Affiliations:MPI für molekulare Genetik
External Affiliations:Gene Center and Department of Chemistry and Biochemistry, University of Munich, Munich, Germany
Identifiers:ISSN:1040-9238
DOI:10.1080/10409230701360843
URL:http://www.informaworld.com/smpp/ftinterface~conte... [Subscribers only]
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