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          Institute: MPI für molekulare Genetik     Collection: Ribosome Research Groups     Display Documents



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ID: 337083.0, MPI für molekulare Genetik / Ribosome Research Groups
Optimized energy consumption for protein synthesis
Authors:Szaflarski, Witold; Nierhaus, Knud H.
Language:English
Date of Publication (YYYY-MM-DD):2007-10
Title of Journal:Origins of Life and Evolution of Biospheres
Volume:37
Issue / Number:4-5
Start Page:423
End Page:428
Copyright:© Springer. Part of Springer Science+Business Media
Review Status:not specified
Audience:Experts Only
Abstract / Description:In our previous contribution (Nierhaus, Orig Life Evol Biosph, this volume, 2007) we mentioned that life had solved the problem of energy supply in three major steps, and that these steps also mark major stages during the development of life. We further outlined a possible scenario concerning a minimal translational apparatus focusing on the essential components necessary for protein synthesis. Here we continue that consideration by addressing on one of the main problems of early life, namely avoiding wasteful energy loss. With regard to the limiting energy supply of early living systems, i.e. those of say more than 3,000 Ma, a carefully controlled and product oriented energy consumption was in demand. In recent years we learned how a bacterial cell avoids energy drain, thus being able to pump most of the energy into protein synthesis. These lessons must be followed by the design of a minimal living system, which is surveyed in this short article.
Free Keywords:Minimal living systems; Protein synthesis; Optimized energy consumption; Idle ribosomes; EF-G
External Publication Status:published
Document Type:Article
Communicated by:Ribosome Group
Affiliations:MPI für molekulare Genetik
Identifiers:ISSN:0169-6149
DOI:10.1007/s11084-007-9091-4
URL:http://www.springerlink.com/content/k78871978u7266...
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