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          Institute: MPI für molekulare Genetik     Collection: Department of Developmental Genetics     Display Documents

ID: 337589.0, MPI für molekulare Genetik / Department of Developmental Genetics
c-Met is essential for wound healing in the skin.
Authors:Chmielowiec, Jolanta; Borowiak, Malgorzata; Morkel, Markus; Stradal, Theresia; Munz, Barbara; Werner, Sabine; Wehland, Jürgen; Birchmeier, Carmen; Birchmeier, Walter
Date of Publication (YYYY-MM-DD):2007-01-01
Title of Journal:The Journal of Cell Biology : JCB
Journal Abbrev.:J. Cell Biol.
Issue / Number:1
Start Page:151
End Page:162
Copyright:© The Rockefeller University Press
Review Status:not specified
Audience:Experts Only
Abstract / Description:Wound healing of the skin is a crucial regenerative process in adult mammals. We examined wound healing in conditional mutant mice, in which the c-Met gene that encodes the receptor of hepatocyte growth factor/scatter factor was mutated in the epidermis by cre recombinase. c-Met–deficient keratinocytes were unable to contribute to the reepithelialization of skin wounds. In conditional c-Met mutant mice, wound closure was slightly attenuated, but occurred exclusively by a few (5%) keratinocytes that had escaped recombination. This demonstrates that the wound process selected and amplified residual cells that express a functional c-Met receptor. We also cultured primary keratinocytes from the skin of conditional c-Met mutant mice and examined them in scratch wound assays. Again, closure of scratch wounds occurred by the few remaining c-Met–positive cells. Our data show that c-Met signaling not only controls cell growth and migration during embryogenesis but is also essential for the generation of the hyperproliferative epithelium in skin wounds, and thus for a fundamental regenerative process in the adult.
Comment of the Author/Creator:Correspondence to: Walter Birchmeier: wbirch@mdc-berlin.de
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Bernhard G. Herrmann
Affiliations:MPI für molekulare Genetik
External Affiliations:1.Department of Cancer Biology and 2.Department of Neuroscience, Max-Delbrück-Center for Molecular Medicine, 13125 Berlin, Germany;
3.Department of Cell Biology, Helmholtz Centre for Infection Research, D-38124 Braunschweig, Germany;
4.Institute of Physiology, Charité-Medical University Berlin, 14195 Berlin, Germany;
5.Institute of Cell Biology, ETH Zürich, Hönggerberg, CH-8093 Zürich, Switzerland.
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