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          Institute: MPI für molekulare Genetik     Collection: Department of Developmental Genetics     Display Documents



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ID: 337591.0, MPI für molekulare Genetik / Department of Developmental Genetics
Expression of Ndufb11 encoding the neuronal protein 15.6 during neurite outgrowth and development.
Authors:Gurok, Ulf; Bork, Kaya; Nuber, Ulrike; Spörle, Ralf; Nöhring, Sabine; Horstkorte, Rüdiger
Language:English
Date of Publication (YYYY-MM-DD):2007-01-02
Title of Journal:Mechanisms of Development: Gene Expression Patterns : Gep ; A Section of Mechanisms of Development
Volume:7
Issue / Number:3
Start Page:370
End Page:374
Copyright:© 2006 Elsevier B.V. All rights reserved.
Review Status:not specified
Audience:Experts Only
Abstract / Description:Neurite outgrowth (e.g. axonal or dendrite outgrowth) of neurons is necessary for the development and functioning of the central nervous system. It is well accepted that the differentiation of neurons and neurite outgrowth involve alterations in gene expression. Furthermore, mitochondria play a role in different aspects of neurite outgrowth. Here we show that the expression of Ndufb11, a gene encoding the mitochondrial protein NP15.6 is decreased in the course of neuronal differentiation. NP15.6 is homologous to the bovine protein ESSS, a component of the mitochondrial complex 1. The homologous human NDUFB11 gene is localized to Xp11.3–Xp11.23, a region associated with neurogenetic disorders. The down-regulation of NP15.6 correlates with neurite outgrowth of PC12 cells induced by nerve growth factor. Furthermore, we analyzed the expression of Ndufb11 in the embryonic and adult mouse.
Comment of the Author/Creator:Corresponding author:
Rüdiger Horstkorte: Tel.: +49 30 8445 1574; fax: +49 30 8445 1541.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Bernhard G. Herrmann
Affiliations:MPI für molekulare Genetik
External Affiliations:1.Institut für Biochemie und Molekularbiologie, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Arnimallee 22, 14195 Berlin-Dahlem, Germany.
Identifiers:ISSN:1567-133X
DOI:10.1016/j.modgep.2006.07.004
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