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          Institute: MPI für Dynamik und Selbstorganisation     Collection: Dynamik komplexer Fluide     Display Documents



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ID: 339887.0, MPI für Dynamik und Selbstorganisation / Dynamik komplexer Fluide
X-ray Microdiffraction on Flow-controlled Biomolecular Assemblies
Authors:Evans, H. M.; Dootz, R.; Köster, S.; Struth, B; Pfohl, T.
Language:English
Date of Publication (YYYY-MM-DD):2007-06
Title of Journal:Bulletin of the Polish Academy of Sciences: Technical Sciences
Volume:55
Issue / Number:2
Start Page:217
End Page:227
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:The study of liquid crystalline assemblies, with an emphasis on biological phenomena, is now accessible using newly developed microdevices integrated with X-ray analysis capability. Many biological systems can be described in terms of gradients, mixing, and confinement, all of which can be mimicked with the use of appropriate microfluidic designs. The use of hydrodynamic focusing creates well-defined mixing conditions that vary depending on parameters such as device geometry, and can be quantified with finite element modelling.We describe experiments in which geometry and strain rate induce finite changes in liquid crystalline orientation. We also demonstrate the online supramolecular assembly of lipoplexes. The measurement of lipoplex orientation as a function of flow velocity allows us to record a relaxation process of the lipoplexes, as evidenced by a remarkable 4-fold azimuthal symmetry. All of these processes are accessible due to the intentional integration of design elements in the microdevices.
External Publication Status:published
Document Type:Article
Communicated by:Folkert Müller-Hoissen
Affiliations:MPI für Dynamik und Selbstorganisation/Dynamik komplexer Fluide
External Affiliations:European Synchrotron Radiation Facility, 6 Jules Horowitz St., BP 220, 38043 Grenoble Cedex, France
Identifiers:URL:http://bulletin.pan.pl/(55-2)217.pdf
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