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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen MPI-CBG 2007     Display Documents

ID: 348507.0, MPI für molekulare Zellbiologie und Genetik / Publikationen MPI-CBG 2007
The Bmp Gradient of the Zebrafish Gastrula Guides Migrating Lateral Cells by Regulating Cell-Cell Adhesion
Authors:Hardt, Sophia von der; Bakkers, Jeroen; Inbal, Adi; Carvalho, Lara; Solnica-Krezel, Lilianna; Heisenberg, Carl-Philipp; Hammerschmidt, Matthias
Date of Publication (YYYY-MM-DD):2007
Title of Journal:Current Biology
Issue / Number:6
Start Page:475
End Page:487
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Background: Bone morphogenetic proteins (Bmps) are
required for the specification of ventrolateral cell fates
during embryonic dorsoventral patterning and for
proper convergence and extension gastrulation movements,
but the mechanisms underlying the latter role
remained elusive.
Results: Via bead implantations, we show that the Bmp
gradient determines the direction of lateral mesodermal
cell migration during dorsal convergence in the zebrafish
gastrula. This effect is independent of its role during
dorsoventral patterning and of noncanonical Wnt signaling.
However, it requires Bmp signal transduction
through Alk8 and Smad5 to negatively regulate Ca2+/
Cadherin-dependent cell-cell adhesiveness. In vivo,
converging mesodermal cells form lamellipodia that attach
to adjacent cells. Bmp signaling diminishes the
Cadherin-dependent stability of such contact points,
thereby abrogating subsequent cell displacement
during lamellipodial retraction.
Conclusions: We propose that the ventral-to-dorsal
Bmp gradient has an instructive role to establish a
reverse gradient of cell-cell adhesiveness, thereby
defining different migratory zones and directing lamellipodia-
driven cell migrations during dorsal convergence
in lateral regions of the zebrafish gastrula.
External Publication Status:published
Document Type:Article
Communicated by:n. n.
Affiliations:MPI für molekulare Zellbiologie und Genetik
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