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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen MPI-CBG 2007     Display Documents

ID: 348527.0, MPI für molekulare Zellbiologie und Genetik / Publikationen MPI-CBG 2007
Rho Regulates Membrane Transport in the Endocytic Pathway to Control Plasma Membrane Specialization in Oligodendroglial Cells
Authors:Kippert, Angelika; Trajkovic, Katarina; Rajendran, Lawrence; Ries, Jonas; Simons, Mikael
Date of Publication (YYYY-MM-DD):2007
Title of Journal:Journal of Neuroscience
Issue / Number:13
Start Page:3560
End Page:3570
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Differentiation of oligodendrocytes is associated with dramatic changes in plasma membrane structure, culminating in the formation of
myelin membrane sheaths. Previous results have provided evidence that regulation of endocytosismayrepresent a mechanism to control
myelin membrane growth. Immature oligodendrocytes have a high rate of clathrin-independent endocytosis for the transport of membrane
to late endosomes/lysosomes (LE/Ls). After maturation and receiving signals from neurons, endocytosis is reduced and transport
of membrane from LE/Ls to the plasma membrane is triggered. Here, we show that changes in Rho GTPase activity are responsible for
switching between these two modes of membrane transport. Strikingly, Rho inactivation did not only reduce the transport of cargo to
LE/L but also increased the dynamics of LE/L vesicles. Furthermore, we provide evidence that Rho inactivation results in the condensation
of the plasma membrane in a polarized manner. In summary, our data reveal a novel role of Rho: to regulate the flow of membrane
and to promote changes in cell surface structure and polarity in oligodendroglial cells. We suggest that Rho inactivation is required to
trigger plasma membrane specialization in oligodendrocytes.
External Publication Status:published
Document Type:Article
Communicated by:n. n.
Affiliations:MPI für molekulare Zellbiologie und Genetik
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