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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen MPI-CBG 2007     Display Documents



ID: 348595.0, MPI für molekulare Zellbiologie und Genetik / Publikationen MPI-CBG 2007
The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and regulates mitotic spindle assembly
Authors:Schlaitz, Anne-Lore; Srayko, Martin; Dammermann, Alexander; Quintin, Sophie; Wielsch, Natalie; MacLeod, Ian; Robillard, Quentin de; Zinke, Andrea; Yates, John R.; Muller-Reichert, Thomas; Shevchenko, Andrej; Oegema, Karen; Hyman, Anthony A.
Date of Publication (YYYY-MM-DD):2007
Title of Journal:Cell
Volume:128
Issue / Number:1
Start Page:115
End Page:127
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Microtubule behavior changes during the cell cycle and during spindle assembly. However, it remains unclear how these changes are regulated and coordinated. We describe a complex that targets the Protein Phosphatase 2A holoenzyme (PP2A) to centrosomes in C. elegans embryos. This complex includes Regulator of Spindle Assembly 1 (RSA-1), a targeting subunit for PP2A, and RSA-2, a protein that binds and recruits RSA-1 to centrosomes. In contrast to the multiple functions of the PP2A catalytic subunit, RSA-1 and RSA-2 are specifically required for microtubule outgrowth from centrosomes and for spindle assembly. The centrosomally localized RSA-PP2A complex mediates these functions in part by regulating two critical mitotic effectors: the microtubule destabilizer KLP-7 and the C. elegans regulator of spindle assembly TPXL-1. By regulating a subset of PP2A functions at the centrosome, the RSA complex could therefore provide a means of coordinating microtubule outgrowth from centrosomes and kinetochore microtubule stability during mitotic spindle assembly.
External Publication Status:published
Document Type:Article
Communicated by:n. n.
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:823
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