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          Institute: MPI für medizinische Forschung     Collection: Abteilung Biomedizinische Optik     Display Documents



ID: 350162.0, MPI für medizinische Forschung / Abteilung Biomedizinische Optik
Topological reorganization of odor representations in the olfactory bulb
Translation of Title:Topological reorganization of odor representations in the olfactory bulb
Authors:Yaksi, Emre; Judkewitz, Benjamin; Friedrich, Rainer W.
Language:English
Date of Publication (YYYY-MM-DD):2007-07-03
Title of Journal:PLoS Biology
Journal Abbrev.:PLoS Biol.
Volume:5
Issue / Number:7
Start Page:1
End Page:21
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Odors are initially represented in the olfactory bulb (OB) by patterns of sensory input across the array of glomeruli. Although activated glomeruli are often widely distributed, glomeruli responding to stimuli sharing molecular features tend to be loosely clustered and thus establish a fractured chemotopic map. Neuronal circuits in the OB transform glomerular patterns of sensory input into spatiotemporal patterns of output activity and thereby extract information about a stimulus. It is, however, unknown whether the chemotopic spatial organization of glomerular inputs is maintained during these computations. To explore this issue, we measured spatiotemporal patterns of odor−evoked activity across thousands of individual neurons in the zebrafish OB by temporally deconvolved two−photon Ca2+ imaging. Mitral cells and interneurons were distinguished by transgenic markers and exhibited different response selectivities. Shortly after response onset, activity patterns exhibited foci of activity associated with certain chemical features throughout all layers. During the subsequent few hundred milliseconds, however, MC activity was locally sparsened within the initial foci in an odor−specific manner. As a consequence, chemotopic maps disappeared and activity patterns became more informative about precise odor identity. Hence, chemotopic maps of glomerular input activity are initially transmitted to OB outputs, but not maintained during pattern processing. Nevertheless, transient chemotopic maps may support neuronal computations by establishing important synaptic interactions within the circuit. These results provide insights into the functional topology of neural activity patterns and its potential role in circuit function.
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Biomedizinische Optik
Identifiers:LOCALID:6806
URI:http%3A%2F%2Fbiology.plosjournals.org%2Fperlserv%2...
URI:http%3A%2F%2Fbiology.plosjournals.org%2Fperlserv%2...
URI:http%3A%2F%2Fbiology.plosjournals.org%2Fperlserv%2...
DOI:10.1371%2Fjournal.pbio.0050178%20
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