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          Institute: MPI für medizinische Forschung     Collection: Abteilung Molekulare Neurobiologie     Display Documents



ID: 350195.0, MPI für medizinische Forschung / Abteilung Molekulare Neurobiologie
Select overexpression of Homer1a in dorsal hippocampus impairs spatial working memory
Translation of Title:Select overexpression of Homer1a in dorsal hippocampus impairs spatial working memory
Authors:Celikel, Tansu; Marx, Verena; Freudenberg, Florian; Zivkovic, Aleksandar; Resnik, Evgeny; Hasan, Mazahir T.; Licznerski, Pawel; Osten, Pavel; Rozov, Andrei; Seeburg, Peter H.; Schwarz, Martin K.
Language:English
Date of Publication (YYYY-MM-DD):2007-09-01
Title of Journal:Frontiers in Neuroscience
Journal Abbrev.:Frontiers in Neuroscience
Volume:1
Start Page:97
End Page:110
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Long Homer proteins forge assemblies of signaling components involved in glutamate receptor signaling in postsynaptic excitatory neurons, including those underlying synaptic transmission and plasticity. The short immediate−early gene (IEG) Homer1a can dynamically uncouple these physical associations by functional competition with long Homer isoforms. To examine the consequences of Homer1a−mediated 'uncoupling' for synaptic plasticity and behavior, we generated forebrain−specific tetracycline−controlled expression of Venus−tagged Homer1a (H1aV) in mice. We report that sustained overexpression of H1aV impaired spatial working but not reference memory. Most notably, a similar impairment was observed when H1aV expression was restricted to the dorsal hippocampus, which identifies this structure as the principal cortical area for spatial working memory. Interestingly, H1aV overexpression also abolished maintenance of CA3−CA1 long−term potentiation (LTP). These impairments, generated by sustained high Homer1a levels, identify a requirement for long Homer forms in synaptic plasticity and temporal encoding of spatial memory.
Free Keywords:hippocampus, viral expression, synaptic plasticity, Homer1a, immediate early gene, spatial reference memory, spatial working memory
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
MPI für medizinische Forschung/Abteilung Zellphysiologie
Identifiers:LOCALID:6881
URI:http%3A%2F%2Fcms.frontiersin.org%2Fcontent%2F10.33...
URI:http%3A%2F%2Ffrontiersin.org%2Fneuroscience%2Fabst...
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