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          Institute: MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut)     Collection: Publikationen des W. G. Kerckhoff-Instituts     Display Documents



ID: 354738.0, MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut) / Publikationen des W. G. Kerckhoff-Instituts
Cardiac stem cells: paradigm shift or broken promise? A view from developmental biology
Authors:Braun, T.; Martire, A.
Date of Publication (YYYY-MM-DD):2007-10
Journal Abbrev.:Trends Biotechnol
Volume:25
Issue / Number:10
Start Page:441
End Page:447
Audience:Not Specified
Abstract / Description:For several decades, it has been known that many tissues of the human body replenish themselves with the help of specialized stem cells. Although the role of stem cells for organs with a rapid cellular turnover is well established, other organs have seemed to be exempt from stem cell-based repair. Recent studies have suggested that the heart has an inherent ability to replace its parenchymal cells continuously either by resident stem cells or by other cells that are recruited into the heart. The evidence for this acclaimed paradigm shift, however, is limited. The basis of the acclaimed beneficial effects of stem cell therapies must be investigated carefully and the fates of potential cardiac stem cells need to be studied by established cell tracing techniques.
Free Keywords:Animals; Cell Differentiation; Developmental Biology/*trends; Humans; *Models, Cardiovascular; Myocytes, Cardiac/*cytology/*physiology; Regeneration/*physiology; Stem Cells/*cytology/*physiology
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für physiologische und klinische Forschung
Identifiers:URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=...
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