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          Institute: MPI für Evolutionsbiologie     Collection: Ecophysiology     Display Documents



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ID: 354868.0, MPI für Evolutionsbiologie / Ecophysiology
Biased distributions and decay of long interspersed nuclear elements in the chicken genome
Authors:Abrusán, György; Krambeck, Hans-Jürgen; Junier, Thomas; Giordano, Joti; Warburton, Peter E.
Language:English
Date of Publication (YYYY-MM-DD):2008-01
Title of Journal:Genetics
Volume:178
Issue / Number:1
Start Page:573
End Page:581
Review Status:not specified
Audience:Not Specified
Abstract / Description:The genomes of birds are much smaller than mammalian genomes, and transposable elements (TEs) make up only 10% of the chicken genome, compared with the 45% of the human genome. To study the mechanisms that constrain the copy numbers of TEs, and as a consequence the genome size of birds, we analyzed the distributions of LINEs (CRI's) and SINEs (MIRs) on the chicken autosomes and Z chromosome. We show that (1) CRI repeats are longest on the Z chromosome and their length is negatively correlated with the local GC content; (2) the decay of CRI elements is highly biased, and the 5'-ends of the insertions are lost much faster than their 3'-ends; (3) the GC distribution of CRI repeats shows a bimodal pattern with repeats enriched in both AT-rich and GC-rich regions of the genome, but the CRI families show large differences in their GC distribution; and (4) the few MIRs in the chicken are most abundant in regions with intermediate GC content. Our results indicate that the primary mechanism that removes repeats front the chicken genome is ectopic exchange and that the low abundance of repeats in avian genomes is likely to be the consequence of their high recombination rates.
External Publication Status:published
Document Type:Article
Affiliations:MPI für Evolutionsbiologie/Abt. Ökophysiologie
External Affiliations:Catholic Univ Louvain, Dept Biol, Lab Aquat Ecol & Evolutionary Biol, Ch Deberiotstr 32, B-3000 Louvain, Belgium; Univ Geneva, Computat Evolutionary Genet Grp 1211, Geneva 4, Switzerland; Mt Sinai Hosp, Mt Sinai Sch Med, Dept Genet & Gen Sci, New York, NY 10029 USA
Identifiers:ISSN:0016-6731 [ID-No:1]
DOI:10.1534/genetics.106.061861 [ID-No:2]
LOCALID:2601/S 38764 [Listen-Nummer/S-Nummer]
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