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          Institute: MPI für Biochemie     Collection: Cell Biology (E. A. Nigg)     Display Documents



ID: 39054.0, MPI für Biochemie / Cell Biology (E. A. Nigg)
Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53(-/-) cells
Authors:Meraldi, P.; Honda, R.; Nigg, E. A.
Language:English
Date of Publication (YYYY-MM-DD):2002-02-15
Title of Journal:EMBO Journal
Journal Abbrev.:Embo J.
Volume:21
Issue / Number:4
Start Page:483
End Page:492
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Aberrations in centrosome numbers have long been implicated in aneuploidy and tumorigenesis, but their origins are unknown. Here we have examined how overexpression of Aurora-A kinase causes centrosome amplification in cultured cells. We show that excess Aurora-A does not deregulate centrosome duplication but gives rise to extra centrosomes through defects in cell division and consequent tetraploidization. Overexpression of other mitotic kinases (Polo-like kinase 1 and Aurora-B) also causes multinucleation and concomitant increases in centrosome numbers. Absence of a p53 checkpoint exacerbates this phenotype, providing a plausible explanation for the centrosome amplification typical of p53(-/-) cells. We propose that errors during cell division, combined with the inability to detect the resulting hyperploidy, constitute a major cause for numerical centrosome aberrations in tumors.
Free Keywords:cancer; cell cycle; chromosomal instability; centrosome anomalies
Comment of the Author/Creator:Date: 2002, FEB 15
External Publication Status:published
Document Type:Article
Communicated by:N.N.
Affiliations:MPI für Biochemie/Cell Biology (E.A. Nigg)
Identifiers:ISI:000174014700001 [ID No:1]
ISSN:0261-4189 [ID No:2]
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