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          Institute: MPI für Psychiatrie     Collection: Publikationen MPI für Psychiatrie     Display Documents

ID: 395626.0, MPI für Psychiatrie / Publikationen MPI für Psychiatrie
Adjunctive lithium treatment in the prevention of suicidal behaviour in depressive disorders: a randomised, placebo-controlled, 1-year trial
Authors:Lauterbach, E.; Felber, W.; Müller-Oerlinghausen, B.; Ahrens, B.; Bronisch, T.; Meyer, T.; Kilb, B.; Lewitzka, U.; Hawellek, B.; Quante, A.; Richter, K.; Broocks, A.; Hohagen, F.
Date of Publication (YYYY-MM-DD):2008-12
Title of Journal:Acta Psychiatrica Scandinavica
Journal Abbrev.:Acta Psychiatr. Scand.
Issue / Number:6
Start Page:469
End Page:479
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Evidence based on controlled studies is still limited for treatment strategies that prevent recurrence of suicide attempts. Findings from observational as well as meta-analytic studies strongly suggest that lithium may have suicide-protective properties. Patients with a recent suicide attempt in the context of an affective spectrum disorder (n = 167) were treated with either lithium or placebo during a 12-month period. Survival analysis showed no significant difference of suicidal acts between lithium and placebo-treated individuals (adjusted hazard ratio 0.517; 95% CI 0.18-1.43). However, post hoc analysis revealed that all completed suicides had occurred in the placebo group accounting for a significant difference in incidence rates (P = 0.049). Results indicate that lithium treatment might be effective in reducing the risk of completed suicide in adult patients with affective disorders. Our findings contribute to the growing body of evidence suggesting a specific antisuicidal effect of lithium.
Free Keywords:suicide; lithium; prevention
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:N. N.
Affiliations:MPI für Psychiatrie
External Affiliations:[Lauterbach, E.; Ahrens, B.; Kilb, B.; Hohagen, F.] Univ Schleswig Holstein, Dept Psychiat & Psychotherapy, Lubeck, Germany.; [Felber, W.; Lewitzka, U.] Tech Univ Dresden, Dept Psychiat & Psychotherapy, Dresden, Germany.; [Mueller-Oerlinghausen, B.; Quante, A.] Charite Univ Med Ctr, Dept Psychiat & Psychotherapy, Berlin, Germany.; [Bronisch, T.] Max Planck Inst Psychiat, D-8000 Munich, Germany.; [Meyer, T.] Univ Lubeck, Inst Social Med, Lubeck, Germany.; [Hawellek, B.] Univ Bonn, Dept Psychiat & Psychotherapy, D-5300 Bonn, Germany.; [Richter, K.] Klinikum Nuremberg Nord, Dept Psychiat & Psychotherapy, Nurnberg, Germany.; [Broocks, A.] Helios Kliniken Schwerin, Schwerin, Germany.
Identifiers:ISI:000260821400007 [ID No:1]
ISSN:0001-690X [ID No:2]
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