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          Institute: MPI für Psychiatrie     Collection: Publikationen MPI für Psychiatrie     Display Documents

ID: 395629.0, MPI für Psychiatrie / Publikationen MPI für Psychiatrie
Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample
Authors:Ludwig, K. U.; Roeske, D.; Schumacher, J.; Schulte-Körne, G.; König, I. R.; Warnke, A.; Plume, E.; Ziegler, A.; Remschmidt, H.; Müller-Myhsok, B.; Nöthen, M. M.; Hoffmann, P.
Date of Publication (YYYY-MM-DD):2008-11
Title of Journal:Journal of Neural Transmission
Journal Abbrev.:J. Neural Transm.
Issue / Number:11
Start Page:1587
End Page:1589
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:The dyslexia susceptibility locus DYX2 (chr. 6p21-p22) harbours two candidate genes, DCDC2 and KIAA0319. In 2006, Harold et al. reported evidence for interaction between both genes. Having previously identified a risk haplotype for dyslexia in DCDC2, but not KIAA0319, in German families, we also tested for interaction between this risk haplotype and KIAA0319. We found a nominally significant association for the quantitative dimension "word reading", the core phenotype in the study of Harold et al., which may be considered as supportive evidence.
Free Keywords:DYX2; Doublecortin domain; Interaction; Reading; Spelling
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für Psychiatrie
External Affiliations:[Ludwig, Kerstin U.; Roeske, Darina; Noethen, Markus M.; Hoffmann, Per] Univ Bonn, Life & Brain Ctr, Dept Genom, D-53105 Bonn, Germany.; [Roeske, Darina; Mueller-Myhsok, Bertram] Max Planck Inst Psychiat, D-80804 Munich, Germany.; [Schumacher, Johannes; Noethen, Markus M.; Hoffmann, Per] Univ Bonn, Inst Human Genet, D-53111 Bonn, Germany.; [Schulte-Koerne, Gerd] Univ Hosp Munich, Dept Child & Adolescent Psychiat & Psychotherapy, D-80336 Munich, Germany.; [Koenig, Inke R.; Ziegler, Andreas] Univ Hosp, Inst Med Biometry & Stat, D-23538 Lubeck, Germany.; [Warnke, Andreas; Plume, Ellen] Univ Wurzburg, Dept Child & Adolescent Psychiat & Psychotherapy, D-97080 Wurzburg, Germany.; [Remschmidt, Helmut] Univ Marburg, Dept Child & Adolescent Psychiat & Psychotherapy, D-35039 Marburg, Germany.
Identifiers:ISI:000260525900013 [ID No:1]
ISSN:0300-9564 [ID No:2]
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