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          Institute: MPI für Evolutionsbiologie     Collection: Evolutionary ecology     Display Documents



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ID: 395907.0, MPI für Evolutionsbiologie / Evolutionary ecology
Cyclic neutropenia in mammals
Authors:Pacheco, Jorge M.; Traulsen, Arne; Antal, Tibor; Dingli, David
Language:English
Date of Publication (YYYY-MM-DD):2008
Title of Journal:American Journal of Hematology
Journal Abbrev.:Am. J. Hematol.
Volume:83
Issue / Number:12
Start Page:920
End Page:921
Review Status:not specified
Audience:Not Specified
Abstract / Description:Cyclic neutropenia (CN) has been well documented in humans and the gray collie. A recent model of the architecture and dynamics of hematopoiesis has been used to provide insights into the mechanism of cycling of this disorder. It provides a link between the cycling period and the cells where the mutated ELA2 is expressed. Assuming that the biologic defect in CN is the same in dogs, and the observation that the structure of hematopoiesis is invariant across mammals, we use allometric scaling techniques to correctly predict the period of cycling in the gray collie and extend it to other mammals from mice to elephants. This work provides additional support for the relevance of animal models to understand disease but cautions that disease dynamics in model animals are different and this has to be taken into consideration when planning experiments
External Publication Status:published
Document Type:Article
Affiliations:MPI für Evolutionsbiologie/Abt. Evolutionsökologie
MPI für Evolutionsbiologie/AG Evolutionstheorie
External Affiliations:ATP-Group, CFTC and Departamento de Física da Faculdade de Ciências, Lisboa Codex, Portugal; Program for Evolutionary Dynamics, Harvard University, Cambridge, Massachusetts;
Division of Hematology, College of Medicine, Mayo Clinic, Rochester, Minnesota
Identifiers:ISSN:0361-8609 (print) [ID-No:1]
ISSN:1096-8652 (onine) [ID-No:2]
DOI:10.1002/ajh.21295 [ID-No:3]
LOCALID:2644/S 38930 [Listen-Nummer/S-Nummer]
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