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Home Search Quick Search Advanced Fulltext Browse Collections Persons My eDoc Session History Login Name: Password: Documentation Help Support Wiki Direct access to document ID:	Institute: MPI für Evolutionsbiologie     Collection: Evolutionary ecology     Display Documents   history ID: 395907.0, MPI für Evolutionsbiologie / Evolutionary ecology Cyclic neutropenia in mammals Authors: Pacheco, Jorge M.; Traulsen, Arne; Antal, Tibor; Dingli, David Language: English Date of Publication (YYYY-MM-DD): 2008 Title of Journal: American Journal of Hematology Journal Abbrev.: Am. J. Hematol. Volume: 83 Issue / Number: 12 Start Page: 920 End Page: 921 Review Status: not specified Audience: Not Specified Abstract / Description: Cyclic neutropenia (CN) has been well documented in humans and the gray collie. A recent model of the architecture and dynamics of hematopoiesis has been used to provide insights into the mechanism of cycling of this disorder. It provides a link between the cycling period and the cells where the mutated ELA2 is expressed. Assuming that the biologic defect in CN is the same in dogs, and the observation that the structure of hematopoiesis is invariant across mammals, we use allometric scaling techniques to correctly predict the period of cycling in the gray collie and extend it to other mammals from mice to elephants. This work provides additional support for the relevance of animal models to understand disease but cautions that disease dynamics in model animals are different and this has to be taken into consideration when planning experiments External Publication Status: published Document Type: Article Affiliations: MPI für Evolutionsbiologie/Abt. Evolutionsökologie MPI für Evolutionsbiologie/AG Evolutionstheorie External Affiliations: ATP-Group, CFTC and Departamento de Física da Faculdade de Ciências, Lisboa Codex, Portugal; Program for Evolutionary Dynamics, Harvard University, Cambridge, Massachusetts; Division of Hematology, College of Medicine, Mayo Clinic, Rochester, Minnesota Identifiers: ISSN:0361-8609 (print) [ID-No:1] ISSN:1096-8652 (onine) [ID-No:2] DOI:10.1002/ajh.21295 [ID-No:3] LOCALID:2644/S 38930 [Listen-Nummer/S-Nummer] Full Text: Sorry, no privileges The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.