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          Institute: MPI für Psychiatrie     Collection: Publikationen MPI für Psychiatrie     Display Documents



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ID: 396556.0, MPI für Psychiatrie / Publikationen MPI für Psychiatrie
Investigation of the DCDC2 intron 2 deletion/compound short tandem repeat polymorphism in a large German dyslexia sample
Authors:Ludwig, K. U.; Schumacher, J.; Schulte-Körne, G.; König, I. R.; Warnke, A.; Plume, E.; Anthoni, H.; Peyrard-Janvid, M.; Meng, H.; Ziegler, A.; Remschmidt, H.; Kere, J.; Gruen, J. R.; Mueller-Myhsok, B.; Nöthen, M. M.; Hoffmann, P.
Language:English
Date of Publication (YYYY-MM-DD):2008-12
Title of Journal:Psychiatric Genetics
Journal Abbrev.:Psychiatr. Genet.
Volume:18
Issue / Number:6
Start Page:310
End Page:312
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Dyslexia is a complex disorder manifested by difficulties in learning to read and spell despite conventional instruction, adequate intelligence and sociocultural opportunity. It is among the most common neurodevelopmental disorders with a prevalence of 5-12%. The dyslexia susceptibility locus 2 on chromosome 6p21-p22 is one of the best-replicated linkage regions in dyslexia. On the basis of systematic linkage disequilibrium studies, the doublecortin domain containing protein 2 gene (DCDC2) was identified as a strong candidate gene in this region. Data from a US study have suggested a complex deletion/compound short tandem repeat (STR) polymorphism in intron 2 of DCDC2 as the causative mutation. In this study, we analyzed this polymorphism in 396 German dyslexia trios which included 376 trios previously providing strong support for the DCDC2 locus. We observed no significant deviation from random transmission, neither for the deletion nor for the alleles of the compound STIR. We also did not find the deletion or any of the STIR alleles to be in linkage disequilibrium with the 2-marker haplotype, which was associated with dyslexia in our sample. We thus conclude that the causative variant/s in DCDC2 conferring susceptibility to dyslexia in our sample remain/s to be identified. Psychiatr Genet 18:310-312 (C) 2008 Wolters Kluwer Health / Lippincott Williams & Wilkins.
Free Keywords:doublecortin domain; dyslexia susceptibility 2; genetic association; reading; spelling
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:N. N.
Affiliations:MPI für Psychiatrie
External Affiliations:[Ludwig, Kerstin U.; Noethen, Markus M.; Hoffmann, Per] Univ Bonn, Dept Genom, Life & Brain Ctr, D-53105 Bonn, Germany.; [Schumacher, Johannes] Univ Bonn, Inst Human Genet, D-53105 Bonn, Germany.; [Schulte-Koerne, Gerd] Univ Hosp Munich, Dept Child & Adolescent Psychiat & Psychotherapy, Munich, Germany.; [Mueller-Myhsok, Bertram] Max Planck Inst Psychiat, D-8000 Munich, Germany.; [Koenig, Inke R.; Ziegler, Andreas] Univ Hosp Schleswig Holstein Campus Lubeck, Inst Med Biometry & Stat, Lubeck, Germany.; [Warnke, Andreas; Plume, Ellen] Univ Wurzburg, Dept Child & Adolescent Psychiat & Psychotherapy, Wurzburg, Germany.; [Remschmidt, Helmut] Univ Marburg, Dept Child & Adolescent Psychiat & Psychotherapy, Marburg, Germany.; [Anthoni, Heidi; Peyrard-Janvid, Myriam; Kere, Juha] Karolinska Inst, Dept Biosci & Nutr, Stockholm, Sweden.; [Anthoni, Heidi; Peyrard-Janvid, Myriam; Kere, Juha] Karolinska Inst, Clin Res Ctr, Stockholm, Sweden.; [Meng, Haiying; Gruen, Jeffrey R.] Yale Univ, Sch Med, Dept Pediat, Yale Child Hlth Res Ctr, New Haven, CT 06510 USA.; [Meng, Haiying; Gruen, Jeffrey R.] Yale Univ, Sch Med, Dept Genet, Yale Child Hlth Res Ctr, New Haven, CT 06510 USA.; [Meng, Haiying; Gruen, Jeffrey R.] Yale Univ, Sch Med, Dept Invest Med, Yale Child Hlth Res Ctr, New Haven, CT 06510 USA.
Identifiers:ISI:000261473800009 [ID No:1]
ISSN:0955-8829 [ID No:2]
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