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          Institute: MPI für Infektionsbiologie     Collection: Department of Immunology     Display Documents



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ID: 400828.0, MPI für Infektionsbiologie / Department of Immunology
Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations
Authors:Hanekom, Willem A.; Dockrell, Hazel M.; Ottenhoff, Tom H. M.; Doherty, T. Mark; Fletcher, Helen; McShane, Helen; Weichold, Frank F.; Hoft, Dan F.; Parida, Shreemanta K.; Fruth, Uli J.
Language:English
Date of Publication (YYYY-MM-DD):2008-07
Title of Journal:PLoS Medicine
Journal Abbrev.:PLos Med.
Volume:5
Issue / Number:7
Start Page:1033
End Page:1036
Sequence Number of Article:145
Copyright:Copyright: © 2008 Hanekom et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:Summary Points
* Many new and diverse tuberculosis vaccines are currently under development.
* The ability to compare clinical immunogenicity between different candidates would be an important asset.
* The World Health Organization (WHO) Initiative for Vaccine Research sponsored three meetings of experts to discuss assay harmonization for new tuberculosis vaccine trials.
* We describe advantages and disadvantages of multiple T cell assay approaches and make specific recommendations for phase I/IIa trials. These include introducing a single and simple harmonised assay for all trials.
External Publication Status:published
Document Type:Article
Communicated by:Hilmar Fünning
Affiliations:MPI für Infektionsbiologie/Department of Immunology
External Affiliations:Univ Cape Town, S African TB Vaccine Initiat, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, Western Cape, South Africa.; London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1, England.; Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, Leiden, Netherlands.; Leiden Univ, Med Ctr, Dept Infect Dis, Leiden, Netherlands.; Statens Serum Inst, Dept Infect Dis Immunol, DK-2300 Copenhagen, Denmark.; Univ Oxford, Ctr Clin Vaccinol & Trop Med, Oxford, England.; Aeras Global TB Vaccine Fdn, Bethesda, MD USA.; St Louis Univ, Hlth Sci Ctr, Dept Internal Med & Mol Microbiol, Div Immunobiol, St Louis, MO 63103 USA.; World Hlth Org, Initiat Vaccine Res, Geneva, Switzerland.
Identifiers:ISI:000257970500008 [ID No:1]
ISSN:1549-1277 [ID No:2]
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