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          Institute: MPI für Evolutionsbiologie     Collection: Evolutionary ecology     Display Documents



  history
ID: 401238.0, MPI für Evolutionsbiologie / Evolutionary ecology
Lifetime reproductive success is maximized with optimal major histocompatibility complex diversity.
Authors:Kalbe, Martin; Eizaguirre, Christophe; Dankert, Ilka; Reusch, Thorsten B. H.; Sommerfeld, Ralf D.; Wegner, K. Mathias; Milinski, Manfred
Language:English
Date of Publication (YYYY-MM-DD):2009-03-07
Title of Journal:Proceedings of the Royal Society of London, Series B
Journal Abbrev.:Proc. R. Soc. B
Volume:276
Issue / Number:1658
Start Page:925
End Page:934
Review Status:not specified
Audience:Not Specified
Abstract / Description:Individual diversity at the major histocompatibility complex (MHC) is predicted to be optimal at intermediate rather than at maximal levels. We showed previously in sticklebacks that an intermediate MHC diversity is predominant in natural populations and provides maximal resistance in experimental multiple parasite infections in the laboratory. However, what counts ultimately is the lifetime reproductive success (LRS). Here, we measured LRS of six laboratory-bred sib-groups-to minimize the influence of non-MHC genes-three-spined sticklebacks (Gasterosteus aculeatus) during their entire breeding period, each in a seminatural enclosure in the lake of their parents, where they were exposed to the natural spectrum of parasites. We collected developing clutches at regular intervals and determined parenthood for a representative number of eggs (2279 in total) per clutch with 18 microsatellites. Both males and females with an intermediate MHC class IIB variant number had the highest LRS. The mechanistic link of MHC diversity and LRS differed between the sexes: in females, we found evidence for a trade-off between number of eggs and immunocompentence, whereas in males this correlation was concealed by different timing strategies of reproduction.
Free Keywords:lifetime reproductive success; major histocompatibility complex; stickleback; parasites; mating decision
External Publication Status:published
Document Type:Article
Affiliations:MPI für Evolutionsbiologie/Abt. Evolutionsökologie
External Affiliations:Institute of Evolution and Biodiversity, Plant Evolutionary Ecology, University of Muenster, Huefferstrasse 1, 48149 Muenster, Germany; Institute of Integrative Biology, Experimental Ecology, ETH-Zentrum, Universitaetstrasse 16, CHN J12.1, 8092 Zurich, Switzerland
Identifiers:ISSN:0962-8452 (print) [ID-No:1]
ISSN:1471-2954 (online) [ID-No:2]
DOI:10.1098/rspb.2008.1466 [ID-No:3]
LOCALID:2668/S 38959 [Listen-Nummer/S-Nummer]
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