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          Institute: MPI für Psychiatrie     Collection: Publikationen MPI für Psychiatrie     Display Documents



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ID: 4022.0, MPI für Psychiatrie / Publikationen MPI für Psychiatrie
Generalized anxiety disorder: comorbidity, comparative biology and treatment
Authors:Nutt, DJ; Ballenger, JC; Sheehan, D; Wittchen, HU
Language:English
Date of Publication (YYYY-MM-DD):2002-12
Title of Journal:International Journal of Neuropsychopharmacology
Journal Abbrev.:Int. J. Neuropsychopharmacol.
Volume:5
Issue / Number:4
Start Page:315
End Page:325
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Generalized anxiety disorder (GAD) is a severe and chronic anxiety disorder characterized by uncontrollable worrying and somatic anxiety (tension, insomnia and hypervigilance). It is a common condition, with lifetime prevalence rates for DSM-IV GAD in the general population of approx. 5-6% being reported. In addition, like other anxiety disorders, GAD also shows comorbidity with depression and most of the other anxiety disorders. This article reviews data on the prevalence of GAD, its comorbidity with depression, and its social and economic impact, Proposed neurobiological mechanisms for GAD are discussed, since an understanding of these may help in the development of future therapies. Finally, current pharmacological and non-pharmacological treatment options for GAD are reviewed, with particular attention being paid to published clinical-trial dat
Free Keywords:antidepressant; comorbidity; generalized anxiety disorder; treatment
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für Psychiatrie
Identifiers:ISI:000180100200005
ISSN:1461-1457
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