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          Institute: MPI für Psychiatrie     Collection: Publikationen MPI für Psychiatrie     Display Documents



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ID: 4025.0, MPI für Psychiatrie / Publikationen MPI für Psychiatrie
The macrophage activity marker sCD14 is increased in patients with multiple sclerosis and upregulated by interferon beta-1b
Authors:Brettschneider, J.; Ecker, D; Bitsch, A; Bahner, D; Bogumil, T; Dressel, A; Elitok, E; Kitze, B; Poser, S; Weber, F; Tumani, H.
Language:English
Date of Publication (YYYY-MM-DD):2002-12
Title of Journal:Journal of Neuroimmunology
Journal Abbrev.:J. Neuroimmunol.
Volume:133
Issue / Number:1-2
Start Page:193
End Page:197
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:The soluble form of the CD14 molecule (sCD14), a macrophage activity marker, was measured in the plasma of 17 patients with primary progressive multiple sclerosis (PPMS) and 20 patients with relapsing remitting MS (RRMS). In patients with PPMS, sCD14 levels were determined before and after treatment with interferon beta (IFNB). In both PPMS and in RRMS, sCD14 levels were significantly elevated compared to healthy controls. In patients with PPMS, sCD14 levels increased significantly during the first 3 months of IFNB therapy, then slightly decreased, but still remained elevated compared with levels before therapy. Therefore, the elevated sCD14 levels may be a marker in evaluating biological response to IFNB therapy. (C) 2002 Elsevier Science B.V. All rights reserved
Free Keywords:multiple sclerosis; primary progressive; relapsing remitting; macrophage activity; sCD14; interferon beta
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für Psychiatrie
Identifiers:ISI:000179874700020
ISSN:0165-5728
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