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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilung 6 - Molecular Biology (D. Weigel)     Display Documents

ID: 402908.0, MPI für Entwicklungsbiologie / Abteilung 6 - Molecular Biology (D. Weigel)
Control of jasmonate biosynthesis and senescence by miR319 targets
Authors:Schommer, C.; Palatnik, J. F.; Aggarwal, P.; Chetelat, A.; Cubas, P.; Farmer, E. E.; Nath, U.; Weigel, D.
Date of Publication (YYYY-MM-DD):2008-09-23
Journal Abbrev.:PLoS Biol
Issue / Number:9
Start Page:e230
Audience:Not Specified
Abstract / Description:Considerable progress has been made in identifying the targets of plant microRNAs, many of which regulate the stability or translation of mRNAs that encode transcription factors involved in development. In most cases, it is unknown, however, which immediate transcriptional targets mediate downstream effects of the microRNA-regulated transcription factors. We identified a new process controlled by the miR319-regulated clade of TCP (TEOSINTE BRANCHED/CYCLOIDEA/PCF) transcription factor genes. In contrast to other miRNA targets, several of which modulate hormone responses, TCPs control biosynthesis of the hormone jasmonic acid. Furthermore, we demonstrate a previously unrecognized effect of TCPs on leaf senescence, a process in which jasmonic acid has been proposed to be a critical regulator. We propose that miR319-controlled TCP transcription factors coordinate two sequential processes in leaf development: leaf growth, which they negatively regulate, and leaf senescence, which they positively regulate.
Free Keywords:Arabidopsis/anatomy & histology/*genetics/*metabolism; Arabidopsis Proteins/genetics/metabolism; Base Sequence; Cell Aging/*physiology; Cyclopentanes/*metabolism; Gene Expression Profiling; *Gene Expression Regulation, Plant; MicroRNAs/genetics/*metabolism; Oxylipins/*metabolism; Plant Leaves/anatomy & histology/physiology; RNA, Plant/genetics/*metabolism; Sequence Alignment; Transcription Factors/genetics/metabolism; Transcription, Genetic
External Publication Status:published
Document Type:Article
Affiliations:MPI für Entwicklungsbiologie/Abteilung 6 - Molekulare Biologie (Detlef Weigel)/
External Affiliations:%G eng
Identifiers:ISSN:1545-7885 (Electronic) %R 07-PLBI-RA-0598 [pii] 10.1371/journal.pbio.0060230
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