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          Institute: MPI für Chemische Physik fester Stoffe     Collection: publications 2009     Display Documents

ID: 404359.0, MPI für Chemische Physik fester Stoffe / publications 2009
Mineralization of biomimetically carboxymethylated collagen fibrils in a model dual membrane diffusion system
Authors:Ehrlich, H.; Hanke, T.; Born, R.; Fischer, C.; Frolov, A.; Langrock, T.; Hoffmann, R.; Schwarzenbolz, U.; Henle, T.; Simon, P.; Geiger, D.; Bazhenov, V. V.; Worch, H.
Date of Publication (YYYY-MM-DD):2009
Title of Journal:Journal of Membrane Science
Journal Abbrev.:J. Membr. Sci.
Start Page:254
End Page:259
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:In the present work, we show for the first time, that N-epsilon-carboxymethyllysine is the major product of the in vitro non-enzymatic glycation reaction between fibrillar collagen and glucuronic acid. Dual diffusion membrane system was effectively used for oriented crystal growth of octacalcium phosphate/hydroxyapatite on the biomimetically carboxymethylated collagen fibrils. We hypothesize that the function of biomimetically carboxymethylated collagen is to increase the local concentration of corresponding ions in such a way that a critical nucleus of ions can be formed, leading to the formation of the mineral under specific micro-environment conditions achieved by using diffusion membrane system. (c) 2008 Elsevier B.V. All rights reserved.
Free Keywords:Dual membrane diffusion system; Collagen; Carboxymethyllysine; Calcium phosphate phases
External Publication Status:published
Document Type:Article
Communicated by:Ina Wanschura
Affiliations:MPI für chemische Physik fester Stoffe
External Affiliations:[Ehrlich, Hermann; Hanke, Thomas; Born, Rene; Worch, Hartmut] Tech Univ Dresden, Max Bergmann Ctr Biomat, D-01069 Dresden, Germany.; [Ehrlich, Hermann; Hanke, Thomas; Born, Rene; Worch, Hartmut] Tech Univ Dresden, Inst Mat Sci, D-01069 Dresden, Germany.; [Fischer, Christiane; Schwarzenbolz, Uwe; Henle, Thomas] Tech Univ Dresden, Inst Food Chem, D-01062 Dresden, Germany.; [Frolov, Andrej; Langrock, Tobias; Hoffmann, Ralf] Univ Leipzig, Ctr Biotechnol & Biomed, Inst Bioanalyt Chem, D-04103 Leipzig, Germany.; [Simon, Paul] Max Planck Inst Chem Phys Solids, D-01187 Dresden, Germany.; [Geiger, Dorin] Speziallabor Triebenberg, D-01328 Dresden, Zaschendorf, Germany.; [Bazhenov, Vasily V.] Far Eastern Natl Univ, Inst Chem & Appl Ecol, Vladivostok 690650, Russia.
Identifiers:ISI:000263006500001 [ID No:1]
ISSN:0376-7388 [ID No:2]
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