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          Institute: MPI für Psychiatrie     Collection: Publikationen MPI für Psychiatrie     Display Documents



ID: 4073.0, MPI für Psychiatrie / Publikationen MPI für Psychiatrie
Microstructure of the non-rapid eye movement sleep electroencephalogram in patients with newly diagnosed Parkinson's disease: Effects of Dopaminergic treatment
Authors:Brunner, H; Wetter, TC; Hoegl, B; Yassouridis, A; Trenkwalder, C; Friess, E
Language:English
Date of Publication (YYYY-MM-DD):2002-09
Title of Journal:Movement Disorders
Journal Abbrev.:Mov. Disord.
Volume:17
Issue / Number:5
Start Page:928
End Page:933
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:We investigated non-rapid eye movement (non-REM) sleep in patients with newly diagnosed Parkinson''s disease (PD) who had never previously received dopaminergic medication. There were no significant differences in the conventional sleep parameters between de novo patients with PD and a healthy control group, but the length of stage I sleep and the number of awakenings increased significantly upon administration of dopaminergic drugs. Analyzing the quantitative electroencephalogram (EEG), we observed a significant reduction in the low-delta frequency range and a nonsignificant increase in the sigma frequency range in de novo patients with PD. The dopaminergic medication also nonsignificantly reduced the low-delta and sigma frequencies, the latter to the level of the controls. Possible mechanisms that may account for the observed differences are discussed. It is suggested that Parkinson''s disease as well as the application of dopaminergic drugs exerts a desynchronizing effect on the sleep EEG that is reflected in a disruption of sleep continuity. (C) 2002 Movement Disorder Society
Free Keywords:Parkinson''s disease; quantitative EEG; EEG power spectrum; non- REM sleep; delta power; dopamine
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für Psychiatrie
Identifiers:ISI:000178384400008
ISSN:0885-3185
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