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          Institute: MPI für molekulare Genetik     Collection: Department of Vertebrate Genomics     Display Documents



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ID: 410728.0, MPI für molekulare Genetik / Department of Vertebrate Genomics
WDR55 is a nucleolar modulator of ribosomal RNA synthesis, cell cycle progression, and teleost organ development
Authors:Iwanami, Norimasa; Higuchi, Tomokazu; Sasano, Yumi; Fujiwara, Toshinobu; Hoa, Vu Q.; Okada, Minoru; Talukder, Sadiqur R.; Kunimatsu, Sanae; Li, Jie; Saito, Fumi; Bhattacharya, Chitralekha; Matin, Angabin; Sasaki, Takashi; Shimizu, Nobuyoshi; Mitani, Hiroshi; Himmelbauer, Heinz; Momoi, Akihiro; Kondoh, Hisato; Furutani-Seiki, Makoto; Takahama, Yousuke
Language:English
Date of Publication (YYYY-MM-DD):2008-08-29
Title of Journal:PLoS Genetics
Journal Abbrev.:PLoS Genet
Volume:4
Issue / Number:8
Start Page:e1000171
End Page:e1000171
Copyright:© 2008 Iwanami et al
Review Status:not specified
Audience:Experts Only
Abstract / Description:The thymus is a vertebrate-specific organ where T lymphocytes are generated. Genetic programs that lead to thymus development are incompletely understood. We previously screened ethylnitrosourea-induced medaka mutants for recessive defects in thymus development. Here we report that one of those mutants is caused by a missense mutation in a gene encoding the previously uncharacterized protein WDR55 carrying the tryptophan-aspartate-repeat motif. We find that WDR55 is a novel nucleolar protein involved in the production of ribosomal RNA (rRNA). Defects in WDR55 cause aberrant accumulation of rRNA intermediates and cell cycle arrest. A mutation in WDR55 in zebrafish also leads to analogous defects in thymus development, whereas WDR55-null mice are lethal before implantation. These results indicate that WDR55 is a nuclear modulator of rRNA synthesis, cell cycle progression, and embryonic organogenesis including teleost thymus development.
Comment of the Author/Creator:E-mail: iwanami@genome.tokushima-u.ac.jp (NI)
External Publication Status:published
Document Type:Article
Communicated by:Hans Lehrach
Affiliations:MPI für molekulare Genetik
External Affiliations:Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima, Japan
Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, Kobe, Japan
Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Kawaguchi, Japan
Department of Cancer Genetics, University of Texas, MD Anderson Cancer Center, Houston, Texas, United States of America
Department of Molecular Biology, Keio University School of Medicine, Tokyo, Japan
GSP Center, The Leading Institute of Keio University, Tsukuba, Japan
Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Japan
Developmental Mutants Group, Kondoh Differentiation Signaling Project, Japan Science and Technology Agency, Kyoto, Japan
Identifiers:ISSN:1553-7404 [eISSN]
DOI:10.1371/journal.pgen.1000171
URL:http://www.plosgenetics.org/article/fetchObjectAtt...
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