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          Institute: MPI für molekulare Genetik     Collection: Department of Vertebrate Genomics     Display Documents



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ID: 410997.0, MPI für molekulare Genetik / Department of Vertebrate Genomics
ConsensusPathDB—a database for integrating human functional interaction networks
Authors:Kamburov, Atanas; Wierling, Christoph; Lehrach, Hans; Herwig, Ralf
Language:English
Date of Publication (YYYY-MM-DD):2008-10-21
Title of Journal:Nucleic Acids Research
Journal Abbrev.:Nucleic Acids Res
Volume:37
Issue / Number:Database issue
Start Page:D623
End Page:D628
Copyright:© 2008 The Author(s)
Review Status:not specified
Audience:Experts Only
Abstract / Description:ConsensusPathDB is a database system for the integration of human functional interactions. Current knowledge of these interactions is dispersed in more than 200 databases, each having a specific focus and data format. ConsensusPathDB currently integrates the content of 12 different interaction databases with heterogeneous foci comprising a total of 26 133 distinct physical entities and 74 289 distinct functional interactions (protein–protein interactions, biochemical reactions, gene regulatory interactions), and covering 1738 pathways. We describe the database schema and the methods used for data integration. Furthermore, we describe the functionality of the ConsensusPathDB web interface, where users can search and visualize interaction networks, upload, modify and expand networks in BioPAX, SBML or PSI-MI format, or carry out over-representation analysis with uploaded identifier lists with respect to substructures derived from the integrated interaction network. The ConsensusPathDB database is available at: http://cpdb.molgen.mpg.de
Comment of the Author/Creator:e-Mail: kamburov@molgen.mpg.de
External Publication Status:published
Document Type:Article
Communicated by:Hans Lehrach
Affiliations:MPI für molekulare Genetik
Identifiers:ISSN:1362-4962 [eISSN]
DOI:10.1093/nar/gkn698
URL:http://nar.oxfordjournals.org/cgi/reprint/37/suppl...
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