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          Institute: MPI für molekulare Genetik     Collection: Department of Human Molecular Genetics     Display Documents



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ID: 411051.0, MPI für molekulare Genetik / Department of Human Molecular Genetics
An integrative approach for analyzing the interplay of genetic and epigenetic changes in tumors
Authors:Muradyan, Artur; Boldt, Vivien; Steininger, Anne; Stabentheiner, Stephanie; Tebel, Katrin; Kreutzberger, Jürgen; Müller, Ines; Madle, Hannelore; Popper, Helmut H.; Ullmann, Reinhard
Language:English
Date of Publication (YYYY-MM-DD):2008-10
Title of Journal:Archives of Pathology and Laboratory Medicine
Volume:132
Issue / Number:10
Start Page:1557
End Page:1561
Copyright:© Copyright by College of American Pathologists 2008
Review Status:not specified
Audience:Experts Only
Abstract / Description:The accumulation of chromosomal aberrations is a characteristic feature of tumor development. However, an understanding of tumorigenesis that assumes that changes in DNA copy number always cause equivalent changes in the corresponding RNA and protein levels is an oversimplification and completely ignores the individual genetic and epigenetic context in which an aberration has to be evaluated. We present a brief introduction to various techniques dedicated to the genome-wide analysis of genetic and epigenetic changes, and illustrate how complementary information derived from these various DNA array-based technologies can lead to a better understanding of the consequences of chromosomal aberrations.
External Publication Status:published
Document Type:Article
Communicated by:Hans-Hilger Ropers
Affiliations:MPI für molekulare Genetik
External Affiliations:1.Institute of Pathology, Medical University of Graz, Graz, Austria.
Identifiers:URL:http://arpa.allenpress.com/pdfserv/10.1043%2F1543-...
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