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          Institute: MPI für Infektionsbiologie     Collection: Department of Molecular Biology     Display Documents



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ID: 411647.0, MPI für Infektionsbiologie / Department of Molecular Biology
Amerindian Helicobacter pylori Strains Go Extinct, as European Strains Expand Their Host Range
Authors:Dominguez-Bello, Maria G.; Perez, Maria E.; Bortolini, Maria C.; Salzano, Francisco M.; Pericchi, Luis R.; Zambrano-Guzman, Orlisbeth; Linz, Bodo
Language:English
Date of Publication (YYYY-MM-DD):2008
Title of Journal:PLoS ONE
Volume:3
Issue / Number:10
Sequence Number of Article:e3307
Copyright:Copyright: © 2008 Domínguez-Bello et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:We studied the diversity of bacteria and host in the H. pylori-human model. The human indigenous bacterium H. pylori diverged along with humans, into African, European, Asian and Amerindian groups. Of these, Amerindians have the least genetic diversity. Since niche diversity widens the sets of resources for colonizing species, we predicted that the Amerindian H. pylori strains would be the least diverse. We analyzed the multilocus sequence (7 housekeeping genes) of 131 strains: 19 cultured from Africans, 36 from Spanish, 11 from Koreans, 43 from Amerindians and 22 from South American Mestizos. We found that all strains that had been cultured from Africans were African strains (hpAfrica1), all from Spanish were European (hpEurope) and all from Koreans were hspEAsia but that Amerindians and Mestizos carried mixed strains: hspAmerind and hpEurope strains had been cultured from Amerindians and hpEurope and hpAfrica1 were cultured from Mestizos. The least genetically diverse H. pylori strains were hspAmerind. Strains hpEurope were the most diverse and showed remarkable multilocus sequence mosaicism (indicating recombination). The lower genetic structure in hpEurope strains is consistent with colonization of a diversity of hosts. If diversity is important for the success of H. pylori, then the low diversity of Amerindian strains might be linked to their apparent tendency to disappear. This suggests that Amerindian strains may lack the needed diversity to survive the diversity brought by non-Amerindian hosts.
Comment of the Author/Creator:Funding: This work was supported by UPR intramural FIPI grant 880314. B.L. was supported by ERA-Net grant BMBF 0313930B to Mark Achtman.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Hilmar Fünning
Affiliations:MPI für Infektionsbiologie/Department of Molecular Biology
External Affiliations:Department of Biology, University of Puerto Rico, San Juan, Puerto Rico, United States of America; Department of Mathematics, University of Puerto Rico, San Juan, Puerto Rico, United States of America; Department of Genetics, Universidade Federal Rio Grande do Sul, Porto Alegre, Brazil; Bilingual Intercultural Department, Universidad Pedagogica Experimental Libertador, Puerto Ayacucho, Venezuela.
Identifiers:ISSN:1932-6203 [ID No:1]
DOI:10.1371/journal.pone.0003307 [ID No:2]
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