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          Institute: MPI für Psychiatrie     Collection: Publikationen MPI für Psychiatrie     Display Documents



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ID: 4126.0, MPI für Psychiatrie / Publikationen MPI für Psychiatrie
Interferon-beta-1b increases serum interleukin-12 p40 levels in primary progressive multiple sclerosis patients
Authors:Bahner, D; Klucke, C; Kitze, B; Elitok, E; Bogumil, T; Dressel, A; Tumani, H; Weber, F; Poser, S; Bitsch, A-
Language:English
Date of Publication (YYYY-MM-DD):2002-06-28
Title of Journal:Neuroscience Letters
Journal Abbrev.:Neurosci. Lett.
Volume:326
Issue / Number:2
Start Page:125
End Page:128
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Serum levels of interleukin-12 heterodimer (IL-12p70) and its homodimeric subunit (IL-12p40) were analyzed by enzyme-linked immunosorbent assay in 18 patients with primary progressive multiple sclerosis (MS) during 3 months before and 3 months under treatment with interferon-beta-1b (IFNbeta-1b, Betaferon(TM), eight million units (MIU) every other day subcutaneously). Median IL-12p40 levels in MS patients before treatment (66.5 and 63.9 pg/ml) were not elevated compared to 18 healthy controls. IL-12p40 significantly increased during treatment (P < 0.0001, median 105.3 pg/ml after 1 month and 95.3 pg/ml after 3 months). Detectable serum levels of IL-12p70 before therapy were only found in one patient. IL-12p70 did not increase during treatment. These data show that immunological processes may also play a role in primary progressive MS and that IFNbeta-1b has an immunomodulating effect in this particular MS subtype. (C) 2002 Published by Elsevier Science Ireland Ltd
Free Keywords:primary progressive multiple sclerosis; interferon-beta-1b; interleukin-12; cytokines
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für Psychiatrie
Identifiers:ISI:000176623000014
ISSN:0304-3940
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