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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen MPI-CBG 2008     Display Documents



ID: 414402.0, MPI für molekulare Zellbiologie und Genetik / Publikationen MPI-CBG 2008
Back and forth between cell fate specification and movement during vertebrate gastrulation
Authors:Heisenberg, Carl-Philipp; Solnica-Krezel, Lilianna
Date of Publication (YYYY-MM-DD):2008
Title of Journal:Current Opinion in Genetics & Development
Volume:18
Issue / Number:4
Start Page:311
End Page:316
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Animal body plan arises during gastrulation and organogenesis by the coordination of inductive events and cell movements. Several signaling pathways, such as BMP, FGF, Hedgehog, Nodal, and Wnt have well-recognized instructive roles in cell fate specification during vertebrate embryogenesis. Growing evidence indicates that BMP, Nodal, and FGF signaling also regulate cell movements, and that they do so through mechanisms distinct from those that specify cell fates. Moreover, pathways controlling cell movements can also indirectly influence cell fate specification by regulating dimensions and relative positions of interacting tissues. The current challenge is to delineate the molecular mechanisms via which the major signaling pathways regulate cell fate specification and movements, and how these two processes are coordinated to ensure normal development.
External Publication Status:published
Document Type:Article
Communicated by:n.n.
Affiliations:MPI f�r molekulare Zellbiologie und Genetik
Identifiers:LOCALID:1156
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