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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen MPI-CBG 2008     Display Documents



ID: 414412.0, MPI für molekulare Zellbiologie und Genetik / Publikationen MPI-CBG 2008
The creation of geometric three-dimensional models of the inner ear based on micro computer tomography data
Authors:Poznyakovskiy, Anton A; Zahnert, Thomas; Kalaidzidis, Yannis; Schmidt, Rolf; Fischer, Björn; Baumgart, Johannes; Yarin, Yury M
Date of Publication (YYYY-MM-DD):2008
Title of Journal:Hearing Research
Volume:243
Issue / Number:1-2
Start Page:95
End Page:104
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:The modeling of the mechanical process of hearing requires an accurate geometrical model of the inner ear (cochlea). The purpose of this study was the creation of a 3-D model of the fluid chambers of Guinea pig cochlea, which could serve as a basis for further mechanical modeling. Micro computer tomography used in this study is a noninvasive method to visualize bony structures. The visualization of the membranous labyrinth was achieved by additional staining of the specimen with OsO(4). The resulting stack of images has been transformed into a cylindrical coordinate system. To suppress noise on tomography images, a nonlinear smoothing method, anisotropic diffusion, were applied. A new approach has been proposed to estimate algorithm parameters automatically. Then, a segmentation using active contours (snakes) was performed. In this study, a new energy linking the contours on adjacent slices has been added to the standard approach. This compensates the inconsistencies between adjacent contours. The images segmented in this way were used as a basis for a 3-D reconstruction of the hearing organ.
External Publication Status:published
Document Type:Article
Communicated by:n.n.
Affiliations:MPI f�r molekulare Zellbiologie und Genetik
Identifiers:LOCALID:1167
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