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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen MPI-CBG 2008     Display Documents



ID: 414415.0, MPI für molekulare Zellbiologie und Genetik / Publikationen MPI-CBG 2008
The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size
Authors:Song, Mi Hye; Aravind, L; Müller-Reichert, Thomas; O'Connell, Kevin F
Date of Publication (YYYY-MM-DD):2008
Title of Journal:Developmental Cell
Volume:15
Issue / Number:6
Start Page:901
End Page:912
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Microtubules are organized by the centrosome, a dynamic organelle that exhibits changes in both size and number during the cell cycle. Here we show that SZY-20, a putative RNA-binding protein, plays a critical role in limiting centrosome size in C. elegans. SZY-20 localizes in part to centrosomes and in its absence centrosomes possess increased levels of centriolar and pericentriolar components including gamma-tubulin and the centriole duplication factors ZYG-1 and SPD-2. These enlarged centrosomes possess normal centrioles, nucleate more microtubules, and fail to properly direct a number of microtubule-dependent processes. Depletion of ZYG-1 restores normal centrosome size and function to szy-20 mutants, whereas loss of szy-20 suppresses the centrosome duplication defects in both zyg-1 and spd-2 mutants. Our results describe a pathway that determines centrosome size and implicate centriole duplication factors in this process.
External Publication Status:published
Document Type:Article
Communicated by:n.n.
Affiliations:MPI f�r molekulare Zellbiologie und Genetik
Identifiers:LOCALID:1171
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