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          Institute: MPI für Psychiatrie     Collection: Publikationen MPI für Psychiatrie     Display Documents



ID: 4155.0, MPI für Psychiatrie / Publikationen MPI für Psychiatrie
Increase in amino acids in the pons after sleep deprivation: A pilot study using proton magnetic resonance spectroscopy
Authors:Murck, H; Struttmann, T; Czisch, M; Wetter, T; Steiger, A; Auer, DP
Language:English
Date of Publication (YYYY-MM-DD):2002
Title of Journal:Neuropsychobiology
Journal Abbrev.:Neuropsychobiology
Volume:45
Issue / Number:3
Start Page:120
End Page:123
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Total sleep deprivation (TSD) is an efficient method to relieve depression. An involvement of GABAergic and glutamatergic neurotransmission in the pathophysiology of depression and the mechanism of action of TSD has been suggested. To directly assess the content of GABA, glutamate (Glu) and glutamine (Gln) before and after TSD, we estimated their concentrations in four brain regions in six healthy subjects using proton magnetic resonance spectroscopy. The unresolved estimate of GABA, Glu and Gln, as well as GABA and Gln were increased in the pons after 24 h of TSD, the effect being prominent in three subjects. There were no significant changes in the hypothalamus, thalamus or parietooccipital cortex. These preliminary data support earlier animal data and indirect findings in humans suggesting that GABA and Gln, especially in the pontine structures, may play a key role in the mechanism of TSD. Copyright (C) 2002 S. Karger AG, Base
Free Keywords:sleep deprivation; NMR; spectroscopy; GABA; glutamate; depression
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für Psychiatrie
Identifiers:ISI:000175589200002
ISSN:0302-282X
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