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          Institute: MPI für Biochemie     Collection: Cellular Biochemistry (F.-U. Hartl)     Display Documents



ID: 41663.0, MPI für Biochemie / Cellular Biochemistry (F.-U. Hartl)
Chaperones increase association of tau protein with microtubules
Authors:Dou, F.; Netzer, W. J.; Tanemura, K.; Li, F.; Hartl, F. U.; Takashima, A.; Gouras, G. K.; Greengard, P.; Xu, H. X.
Language:English
Date of Publication (YYYY-MM-DD):2003-01-21
Title of Journal:Proceedings of the National Academy of Sciences of the United States of America
Journal Abbrev.:Proc. Natl. Acad. Sci. U. S. A.
Volume:100
Issue / Number:2
Start Page:721
End Page:726
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Molecular chaperones and their functions in protein folding have been implicated in several neurodegenerative diseases, including Parkinson's disease and Huntington's disease, which are characterized by accumulation of protein aggregates (e.g., alpha-synuclein and huntingtin, respectively). These aggregates have been shown in various experimental systems to respond to changes in levels of molecular chaperones suggesting the possibility of therapeutic intervention and a role for chaperones in disease pathogenesis. It remains unclear whether chaperones also play a role in Alzheimer's disease, a neurodegenerative disorder characterized by beta-amyloid and tau protein aggregates. Here, we report an inverse relationship between aggregated tau and the levels of heat shock protein (Hsp)70/90 in tau transgenic mouse and Alzheimer's disease brains. In various cellular models, increased levels of Hsp70 and Hsp90 promote tau solubility and tau binding to microtubules, reduce insoluble tau and cause reduced tau phosphorylation. Conversely, lowered levels of Hsp70 and Hsp90 result in the opposite effects. We have also demonstrated a direct association of the chaperones with tau proteins. Our results suggest that up-regulation of molecular chaperones may suppress formation of neurofibrillary tangles by partitioning tau into a productive folding pathway and thereby preventing tau aggregation.
Comment of the Author/Creator:Date: 2003, JAN 21
External Publication Status:published
Document Type:Article
Communicated by:N.N.
Affiliations:MPI für Biochemie/Cellular Biochemistry (F.-U. Hartl)
External Affiliations:Rockefeller Univ, Fisher Ctr Res Alzheimers Dis, 1230 York Ave,; New York, NY 10021 USA; Rockefeller Univ, Fisher Ctr Res Alzheimers Dis, New York, NY 10021 USA; Rockefeller Univ, Mol & Cellular Neurosci Lab, New York, NY 10021 USA; Inst Phys & Chem Res, Lab Alzheimers Dis, Wako, Saitama 3510198, Japan; Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USA
Identifiers:ISI:000180589000062 [ID No:1]
ISSN:0027-8424 [ID No:2]
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