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          Institute: MPI für Biochemie     Collection: Independent Junior Research Groups     Display Documents



ID: 41693.0, MPI für Biochemie / Independent Junior Research Groups
SMN-mediated assembly of RNPs: a complex story
Authors:Meister, G.; Eggert, C.; Fischer, U.
Language:English
Date of Publication (YYYY-MM-DD):2002-10
Title of Journal:Trends in Cell Biology
Journal Abbrev.:Trends Cell Biol.
Volume:12
Issue / Number:10
Start Page:472
End Page:478
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Although many RNA-protein complexes or ribonucleoproteins (RNPs) assemble spontaneously in vitro, little is known about how they form in the environment of a living cell. Insight into RNP assembly has come unexpectedly from functional analyses of the survival motor neuron (SMN) protein, a gene product that is affected in the neuromuscular disease spinal muscular atrophy. These studies show that the assembly of spliceosomal U-rich small nuclear RNPs in vivo depends on the activity of two large protein complexes, one of which contains the SMN protein. These complexes might also facilitate the assembly of other cellular RNPs.
Comment of the Author/Creator:Date: 2002, OCT
External Publication Status:published
Document Type:Article
Communicated by:N.N.
Affiliations:MPI für Biochemie/Independent Junior Research Groups/RNA Metabolism and Neuronal Diseases (U. Fischer)
Identifiers:ISI:000178297400011 [ID No:1]
ISSN:0962-8924 [ID No:2]
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