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          Institute: MPI für Biochemie     Collection: Molecular Biology (A. Ullrich)     Display Documents

ID: 41779.0, MPI für Biochemie / Molecular Biology (A. Ullrich)
Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alpha v integrins
Authors:McCarty, J. H.; Monahan-Earley, R. A.; Brown, L. F.; Keller, M.; Gerhardt, H.; Rubin, K.; Shani, M.; Dvorak, H. F.; Wolburg, H.; Bader, B. L.; Dvorak, A. M.; Hynes, R. O.
Date of Publication (YYYY-MM-DD):2002-11
Title of Journal:Molecular and Cellular Biology
Journal Abbrev.:Mol. Cell. Biol.
Issue / Number:21
Start Page:7667
End Page:7677
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Mouse embryos genetically null for the alphav integrin subunit develop intracerebral hemorrhages at midgestation and die shortly after birth. A key question is whether the hemorrhage arises from primary defects in vascular endothelial cells or pericytes or from other causes. We have previously reported normal initiation of cerebral vessels comprising branched tubes of endothelial cells. Here we show that the onset of hemorrhage is not due to defects in pericyte recruitment. Additionally, most alphav-null vessels display ultrastructurally normal endothelium-pericyte associations and normal interendothelial cell junctions. Thus, endothelial cells and pericytes appear to establish their normal relationships in cerebral microvessels. However, by both light and electron microscopy, we detected defective associations between cerebral microvessels and the surrounding brain parenchyma, composed of neuroepithelial cells, glia, and neuronal precursors. These data suggest a novel role for alphav integrins in the association between cerebral microvessels and central nervous system parenchymal cells.
Comment of the Author/Creator:Date: 2002, NOV
External Publication Status:published
Document Type:Article
Communicated by:N.N.
Affiliations:MPI für Biochemie/Molecular Biology (A. Ullrich)/Research Group B. Bader
External Affiliations:MIT, Howard Hughes Med Inst, E17-230, Cambridge, MA 02139 USA; MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA; MIT, Ctr Canc Res, Cambridge, MA 02139 USA; Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02215 USA; Harvard Univ, Sch Med, Boston, MA 02215 USA; Univ Tubingen, Inst Pathol, D-7400 Tubingen, Germany; Univ Uppsala, Dept Med & Physiol Chem, Uppsala, Sweden; Volcani Inst, Inst Anim Sci, Bet Dagan, Israel
Identifiers:ISI:000178586900030 [ID No:1]
ISSN:0270-7306 [ID No:2]
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