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          Institute: MPI für Psychiatrie     Collection: Publikationen MPI für Psychiatrie     Display Documents

ID: 4186.0, MPI für Psychiatrie / Publikationen MPI für Psychiatrie
Parental major depression and the risk of depression and other mental disorders in offspring - A prospective-longitudinal community study
Authors:Lieb, R; Isensee, B; Höfler, M; Pfister, H; Wittchen, HU
Date of Publication (YYYY-MM-DD):2002-04
Title of Journal:Archives of General Psychiatry
Journal Abbrev.:Arch. Gen. Psychiatry
Issue / Number:4
Start Page:365
End Page:374
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Background: This article examines associations between DSM-IV depressive disorders, their natural course, other psychopathology, and parental major depression in a community sample of adolescents and young adults. Methods: Baseline and 4-year follow-up data were used from the Early Developmental Stages of Psychopathology Study, a prospective-longitudinal community study of adolescents and young adults. Results are based on 2427 subjects who completed the follow-up and for whom diagnostic information for both parents was available. DSM-IV mental disorders in respondents were assessed using the Munich- Composite International Diagnostic Interview. Information on depression in parents was collected as family history information from the respondents and from diagnostic interviews with parents of the younger cohort. Results: Offspring with I (odds ratio [OR], 2.7; 95% confidence interval [ C1], 2.1-3.5) or 2 affected parents (OR, 3.0; 95% Cl, 2.2-4.1) had an increased risk for depression. They also had a higher risk for substance use (I parent affected: OR, 1.4; 95% Cl, 1.1-1.7; both parents affected: OR, 1.4; 95% Cl, 1.0-1.8) and anxiety disorders (I parent affected: OR, 1.6; 95% CI, 1.3-1.9; both parents affected: OR, 2.1; 95% Cl, 1.6-2.8). There were no differences whether mother or father was affected. Parental depression was associated with an earlier onset and a more malignant course (severity, impairment, recurrence) of depressive disorders in offspring. Conclusions: Major depression in parents increases the overall risk in offspring for onset of depressive and other mental disorders and influences patterns of the natural course of depression in the early stages of manifestatio
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für Psychiatrie
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