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          Institute: MPI für biologische Kybernetik     Collection: Biologische Kybernetik     Display Documents



ID: 419870.0, MPI für biologische Kybernetik / Biologische Kybernetik
Smart Magnetic Resonance Imaging Agents that Sense Extracellular Calcium Fluctuations
Authors:Angelovski, G.; Fouskova, P.; Mamedov, I.; Canals, S.; Toth, E.; Logothetis, N.K.
Date of Publication (YYYY-MM-DD):2008-07
Title of Journal:ChemBioChem
Volume:9
Issue / Number:11
Start Page:1729
End Page:1734
Audience:Not Specified
Intended Educational Use:No
Abstract / Description:Gd3+ chelates linked to a modified EGTA moiety were prepared in order to
respond to extracellular Ca2+ fluctuations in the brain











Gd3+ chelates linked to a
modified EGTA moiety were prepared in order to respond to extracellular Ca2+
fluctuations in the brain. Upon interaction with Ca2+, they exhibit
high and reversible relaxivity changes in buffered solution or in a model of
the brain extracellular medium. These efficient Ca2+ magnetic
resonance imaging sensors might open new perspectives in functional molecular
imaging.
External Publication Status:published
Document Type:Article
Communicated by:Holger Fischer
Affiliations:MPI f�r biologische Kybernetik/Neurophysiology (Dept. Logothetis)
Identifiers:LOCALID:5082
URL:http://www3.interscience.wiley.com/cgi-bin/fulltex...
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