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          Institute: MPI für biologische Kybernetik     Collection: Biologische Kybernetik     Display Documents

ID: 419979.0, MPI für biologische Kybernetik / Biologische Kybernetik
The microvascular system of the striate and extrastriate visual cortex of the macaque
Authors:Weber, B.; Keller, A.L.; Reichold, J.; Logothetis, N.K.
Date of Publication (YYYY-MM-DD):2008-10
Title of Journal:Cerebral Cortex
Issue / Number:10
Start Page:2318
End Page:2330
Audience:Not Specified
Intended Educational Use:No
Abstract / Description:In functional neuroimaging, neurovascular coupling is used to generate maps of
hemodynamic changes that are assumed to be surrogates of regional neural activation.
The aim of this study was to characterize the microvascular system of the primate cortex
as a basis for understanding the constraints imposed on a region’s hemodynamic response
by the architecture, density, as well as area- and layer-specific variations in the
cerebrovascular system. In the macaque visual cortex, an array of anatomical techniques
has been applied, including corrosion casts, immunohistochemistry and cytochrome
oxidase staining. Detailed measurements of regional vascular length density, mean
volume fraction, and surface density revealed a similar vascularization in different visual
areas. The laminar profile of the vascular parameters was only weakly related to the
number of neurons and synapses, but it was strongly correlated with the steady-state
metabolic demand as measured by cytochrome oxidase activity. This observation
suggests that while the number of neurons and synapses determine an upper bound on an
area’s integrative capacity, its vascularization reflects the neural activity of those
subpopulations that represent a “default” mode of brain steady-state. In addition to the
novel quantitative description of the primate cortical microvascular system, these
findings have important implications for functional neuroimaging.
External Publication Status:published
Document Type:Article
Communicated by:Holger Fischer
Affiliations:MPI f�r biologische Kybernetik/Neurophysiology (Dept. Logothetis)
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