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          Institute: MPI für Neurobiologie     Collection: Cellular and Systems Neurobiology     Display Documents

ID: 420145.0, MPI für Neurobiologie / Cellular and Systems Neurobiology
Serine phosphorylation of ephrinB2 regulates trafficking of synaptic AMPA receptors
Authors:Essmann, C. L.; Martinez, E.; Geiger, J. C.; Zimmer, M.; Traut, M. H.; Stein, V.; Klein, R.; Acker-Palmer, A.
Date of Publication (YYYY-MM-DD):2008-09
Title of Journal:Nature Neuroscience
Journal Abbrev.:Nat. Neurosci.
Issue / Number:9
Start Page:1035
End Page:1043
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:Plasticity in the brain is essential for maintaining memory and learning and is associated with the dynamic membrane trafficking of AMPA receptors. EphrinB proteins, ligands for EphB receptor tyrosine kinases, are transmembrane molecules with signaling capabilities that are required for spine morphogenesis, synapse formation and synaptic plasticity. Here, we describe a molecular mechanism for ephrinB2 function in controlling synaptic transmission. EphrinB2 signaling is critical for the stabilization of AMPA receptors at the cellular membrane. Mouse hippocampal neurons from conditional ephrinB2 knockouts showed enhanced constitutive internalization of AMPA receptors and reduced synaptic transmission. Mechanistically, glutamate receptor interacting proteins bridge ephrinB ligands and AMPA receptors. Moreover, this function involved a regulatory aspect of ephrinB reverse signaling that involves the phosphorylation of a single serine residue in their cytoplasmic tails. In summary, our findings uncover a model of cooperative AMPA receptor and ephrinB reverse signaling at the synapse.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Affiliations:MPI für Neurobiologie/Molecular Neurobiology (Klein)/Signal Transduction (Palmer; 2001-2008)
MPI für Neurobiologie/Cellular and Systems Neurobiology (Bonhoeffer)/Synaptic Receptor Trafficking (Stein)
MPI für Neurobiologie/Molecular Neurobiology (Klein)
External Affiliations:[Essmann, Clara L.; Geiger, Julia C.; Acker-Palmer, Amparo] Univ Frankfurt, Inst Cell Biol & Neurosci, D-60438 Frankfurt, Germany.;
Identifiers:ISI:000258720000013 [ID No:1]
ISSN:1097-6256 [ID No:2]
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